Sepsis: network pathophysiology and implications for early diagnosis

J Arora, AA Mendelson… - American Journal of …, 2023 - journals.physiology.org
Sepsis, a medical emergency, is the overwhelming host response to infection leading to
organ failure. The pathophysiology of this heterogeneous disease includes an inflammatory …

[HTML][HTML] Recent nanoengineered diagnostic and therapeutic advancements in management of Sepsis

M Soni, M Handa, KK Singh, R Shukla - Journal of Controlled Release, 2022 - Elsevier
COVID-19 acquired symptoms have affected the worldwide population and increased the
load of Intensive care unit (ICU) patient admissions. A large number of patients admitted to …

[HTML][HTML] Evaluation of qSOFA combined with inflammatory mediators for diagnosing sepsis and predicting mortality among emergency department

H Ling, M Chen, JJ Dai, H Zhong, R Chen, F Shi - Clinica chimica acta, 2023 - Elsevier
Background There are no guidelines in China or worldwide that clearly recommend
indicators for the early diagnosis of sepsis in the emergency department. Simple and unified …

Protective role of the novel cytokine Metrnl/interleukin-41 in host immunity defense during sepsis by promoting macrophage recruitment and modulating Treg/Th17 …

X Chen, X Chen, Y Yang, N Luo, J Yang, L Zhong… - Clinical …, 2023 - Elsevier
Background Metrnl play an immunocytokine-like role in several diseases, which is also
known as meteorin-like because it is homologous to the neurotrophic factor meteorin …

Randomized clinical trial of antioxidant therapy patients with septic shock and organ dysfunction in the ICU: SOFA score reduction by improvement of the enzymatic …

A Aisa-Álvarez, I Pérez-Torres, V Guarner-Lans… - Cells, 2023 - mdpi.com
Background and aim: Here, we assess the effect of adjuvant antioxidant therapies in septic
shock patients with organ dysfunction and their effect on the enzymatic and non-enzymatic …

Pathogenesis of Anemia in Canine Babesiosis: Possible Contribution of Pro-Inflammatory Cytokines and Chemokines—A Review

W Zygner, O Gójska-Zygner, LJ Norbury - Pathogens, 2023 - mdpi.com
Canine babesiosis is a tick-borne protozoan disease caused by intraerythrocytic parasites of
the genus Babesia. The infection may lead to anemia in infected dogs. However, anemia is …

Plasminogen system in the pathophysiology of sepsis: upcoming biomarkers

F Napolitano, V Giudice, C Selleri… - International Journal of …, 2023 - mdpi.com
Severe hemostatic disturbances and impaired fibrinolysis occur in sepsis. In the most
serious cases, the dysregulation of fibrinolysis contributes to septic shock, disseminated …

Inflammation-responsive drug delivery nanosystems for treatment of bacterial-induced sepsis

VO Nyandoro, CA Omolo, EA Ismail, L Yong… - International Journal of …, 2023 - Elsevier
Sepsis, a complication of dysregulated host immune systemic response to an infection, is life
threatening and causes multiple organ injuries. Sepsis is recognized by WHO as a big …

An immune-related gene signature predicts the 28-day mortality in patients with sepsis

Y Peng, Q Wu, H Liu, J Zhang, Q Han, F Yin… - Frontiers in …, 2023 - frontiersin.org
Introduction Sepsis is the leading cause of death in intensive care units and is characterized
by multiple organ failure, including dysfunction of the immune system. In the present study …

The Immunomodulatory Activity of Punica granatum L. Peel Extract Increases the Lifespan of Mice with Lethal Sepsis

L de O. Trovão, L dos S. Rodrigues… - Journal of …, 2023 - Wiley Online Library
Sepsis is an organ dysfunction syndrome associated with high mortality. To date, no
effective treatment is available to combat this disease. Punica granatum L. is a potential …