Despite the long-standing observation of vast neuronal loss in Alzheimer's disease (AD) our
understanding of how and when neurons are eliminated is incomplete. While previous …

Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

In neurodegenerative diseases, microglia switch to an activated state, which results in
excessive secretion of pro-inflammatory factors. Our work aims to investigate how this …

Background Neuroinflammation is a crucial factor in the development of secondary brain
injury after intracerebral hemorrhage (ICH). Irisin is a newly identified myokine that confers …

Stroke has caused tremendous social stress worldwide, yet despite decades of research
and development of new stroke drugs, most have failed and rt-PA (Recombinant tissue …

Intracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of mortality
and morbidity. It induces cell death that is responsible for neurological deficits postinjury …

Background Owing to metabolic disequilibrium and immune suppression, intracerebral
hemorrhage (ICH) patients are prone to infections; according to a recent global analysis of …

Inflammasomes are molecular scaffolds that are activated by damage-associated and
pathogen-associated molecular patterns and form a key element of innate immune …

As a ligand-dependent transcription factor, retinoid-associated orphan receptor γt (RORγt)
that controls T helper (Th) 17 cell differentiation and interleukin (IL)-17 expression plays a …

BACKGROUND: Intracerebral hemorrhage (ICH) causes severe sensorimotor dysfunction
and cognitive decline which are aggravated by secondary brain injury, yet there are no …