[HTML][HTML] A systematic review of computational approaches to understand cancer biology for informed drug repurposing
Cancer is the second leading cause of death globally, trailing only heart disease. In the
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …
Time‐delayed models of gene regulatory networks
K Parmar, KB Blyuss, YN Kyrychko… - … methods in medicine, 2015 - Wiley Online Library
We discuss different mathematical models of gene regulatory networks as relevant to the
onset and development of cancer. After discussion of alternative modelling approaches, we …
onset and development of cancer. After discussion of alternative modelling approaches, we …
[HTML][HTML] A machine learning and directed network optimization approach to uncover TP53 regulatory patterns
CP Triantafyllidis, A Barberis, F Hartley, AM Cuervo… - Iscience, 2023 - cell.com
TP53, the Guardian of the Genome, is the most frequently mutated gene in human cancers
and the functional characterization of its regulation is fundamental. To address this we …
and the functional characterization of its regulation is fundamental. To address this we …
Identification of critical regulatory genes in cancer signaling network using controllability analysis
Cancer is characterized by a complex web of regulatory mechanisms which makes it difficult
to identify features that are central to its control. Molecular integrative models of cancer …
to identify features that are central to its control. Molecular integrative models of cancer …
Comparative analysis of differential network modularity in tissue specific normal and cancer protein interaction networks
MF Islam, MM Hoque, RS Banik, S Roy… - Journal of clinical …, 2013 - Springer
Background Large scale understanding of complex and dynamic alterations in cellular and
subcellular levels during cancer in contrast to normal condition has facilitated the …
subcellular levels during cancer in contrast to normal condition has facilitated the …
[PDF][PDF] Changes in protein interaction networks between normal and cancer conditions: Total chaos or ordered disorder?
New insights to understand the dynamics of enormous modifications during cancer in
comparison to healthy condition have made the ground for the emergence of sophisticated …
comparison to healthy condition have made the ground for the emergence of sophisticated …
Data Mining Mycobacterium tuberculosis Pathogenic Gene Transcription Factors and Their Regulatory Network Nodes
G Yuan, Y Bai, Y Zhang, G Xu - International Journal of …, 2018 - Wiley Online Library
Tuberculosis (TB) is one of the deadliest infectious diseases worldwide. In Mycobacterium
tuberculosis, changes in gene expression are highly variable and involve many genes, so …
tuberculosis, changes in gene expression are highly variable and involve many genes, so …
Building Graphs To Describe Dynamics, Kinetics, and Energetics in the d-ALa:d-Lac Ligase VanA
The d-Ala: d-Lac ligase, VanA, plays a critical role in the resistance of vancomycin. Indeed, it
is involved in the synthesis of a peptidoglycan precursor, to which vancomycin cannot bind …
is involved in the synthesis of a peptidoglycan precursor, to which vancomycin cannot bind …
Modelling the role of dual specificity phosphatases in herceptin resistant breast cancer cell lines
Background Breast cancer remains the most lethal type of cancer for women. A significant
proportion of breast cancer cases are characterised by overexpression of the human …
proportion of breast cancer cases are characterised by overexpression of the human …
Reconstructing the functional effect of TP53 somatic mutations on its regulon using causal signalling network modelling
The gene encoding tumor protein p53 (TP53) is the most frequently mutated gene in human
cancer. Mutations in both coding and non-coding regions of TP53 can disrupt the regulatory …
cancer. Mutations in both coding and non-coding regions of TP53 can disrupt the regulatory …