Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

A role for advanced glycation end products in molecular ageing

K Zgutka, M Tkacz, P Tomasiak… - International journal of …, 2023 - mdpi.com
Ageing is a composite process that involves numerous changes at the cellular, tissue, organ
and whole-body levels. These changes result in decreased functioning of the organism and …

Recent updates in anti-glycation strategies: selection of natural products and lactic acid bacteria as potential inhibitors based on the multi-pathway anti-glycation …

K Yue, B Mao, X Tang, Q Zhang, J Zhao… - Critical Reviews in …, 2023 - Taylor & Francis
The prevalence of high-sugar diets and unhealthy habits exacerbates the production of
advanced glycation end products (AGEs) in the body. When AGEs excessively accumulate …

N-Acetylcysteine, an ROS Inhibitor, Alleviates the Pathophysiology of Hyperthyroidism-Induced Cardiomyopathy via the ROS/Ca2+ Pathway

M Bao, X Hua, H Mo, Z Sun, B Xu, X Chen, M Xu, X Xu… - Biomolecules, 2022 - mdpi.com
Hyperthyroidism is common and can induce cardiomyopathy, but there is no effective
therapeutic strategy. The purpose of this study was to investigate the molecular mechanism …

Organosulfurs, S-allyl cysteine and N-acetyl cysteine sequester di-carbonyls and reduces carbonyl stress in HT22 cells

R Bhattacharya, S Saini, S Ghosh, P Roy, N Ali… - Scientific Reports, 2023 - nature.com
Diabetes, characterized by high blood glucose level, is a progressive metabolic disease that
leads to serious health complications. One of the major pathological consequences …

Uncovering chemical profiles, biological potentials, and protection effect against ECM destruction in H2O2‐treated HDF cells of the extracts of Stachys tundjeliensis

I Kurt‐Celep, D Zheleva‐Dimitrova… - Archiv der …, 2024 - Wiley Online Library
The genus Stachys L., one of the largest genera of the Lamiaceae family, is highly
represented in Turkey. This study was conducted to determine the bio‐pharmaceutical …

Structure‒function‒pathogenicity analysis of C-terminal myocilin missense variants based on experiments and 3D models

B Zhou, X Lin, Z Li, Y Yao, J Yang, Y Zhu - Frontiers in Genetics, 2022 - frontiersin.org
MYOC is a common pathogenic gene for primary open-angle glaucoma and encodes the
protein named myocilin. Multiple MYOC variations have been found, with different clinical …

A novel lncRNA TCONS_00071187 upregulated by activated GSK3β promotes high glucose-induced mesangial cell proliferation in the diabetic nephropathy

Z Yang, X Sun, X Deng, W Jiang, Z Zhang… - Cellular and Molecular …, 2024 - cellmolbiol.org
Inhibiting mesangial cell proliferation is one of the strategies to control the early progression
of diabetic nephropathy (DN). GSK3β is closely related to cell apoptosis as well as the …

[PDF][PDF] OxiSelect™ Advanced Glycation End Product (AGE) Competitive ELISA Kit, Trial Size

P Manual - cellbiolabs.com
The non-enzymatic reaction of reducing carbohydrates with lysine side chains and N-
terminal amino groups of macromolecules (proteins, phospholipids and nucleic acids) is …

[PDF][PDF] OxiSelect™ Advanced Glycation End Product (AGE) Competitive ELISA Kit

P Manual - cellbiolabs.com
The non-enzymatic reaction of reducing carbohydrates with lysine side chains and N-
terminal amino groups of macromolecules (proteins, phospholipids and nucleic acids) is …