Integrated and patient-centred management of Parkinson's disease: a network model for reshaping chronic neurological care

BR Bloem, EJ Henderson, ER Dorsey… - The Lancet …, 2020 - thelancet.com
Chronic neurological diseases are the leading cause of disability globally. Yet, our health-
care systems are not designed to meet the needs of many patients with chronic neurological …

Interplay between MicroRNAs and oxidative stress in neurodegenerative diseases

J Konovalova, D Gerasymchuk, I Parkkinen… - International journal of …, 2019 - mdpi.com
MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal
differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis …

Targeted suppression of mTORC2 reduces seizures across models of epilepsy

J Okoh, J Mays, A Bacq, JA Oses-Prieto… - Nature …, 2023 - nature.com
Epilepsy is a neurological disorder that poses a major threat to public health.
Hyperactivation of mTOR complex 1 (mTORC1) is believed to lead to abnormal network …

Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke

Y Xia, X Ling, G Hu, Q Zhu, J Zhang, Q Li… - Stem cell research & …, 2020 - Springer
Background Small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSC)
derived from human induced pluripotent stem cells (iPSC, iMSC-sEV) are considered to …

Roles of gut microbiome in epilepsy risk: a Mendelian randomization study

Y Zeng, S Cao, H Yang - Frontiers in Microbiology, 2023 - frontiersin.org
Background Recent studies have suggested an association between gut microbiomes
(GMs) and epilepsy. However, the GM taxa identified in different studies are variable. In …

Platelets as mediators of neuroinflammation and thrombosis

E Rawish, H Nording, T Münte, HF Langer - Frontiers in immunology, 2020 - frontiersin.org
Beyond platelets function in hemostasis, there is emerging evidence to suggest that platelets
contribute crucially to inflammation and immune responses. Therefore, considering the …

Mitochondrial oxidative stress and “mito-inflammation”: actors in the diseases

S Patergnani, E Bouhamida, S Leo, P Pinton… - Biomedicines, 2021 - mdpi.com
A decline in mitochondrial redox homeostasis has been associated with the development of
a wide range of inflammatory-related diseases. Continue discoveries demonstrate that …

You've got male: Sex and the microbiota-gut-brain axis across the lifespan

M Jaggar, K Rea, S Spichak, TG Dinan… - Frontiers in …, 2020 - Elsevier
Sex is a critical factor in the diagnosis and development of a number of mental health
disorders including autism, schizophrenia, depression, anxiety, Parkinson's disease …

Phosphatidylserine, inflammation, and central nervous system diseases

X Ma, X Li, W Wang, M Zhang, B Yang… - Frontiers in aging …, 2022 - frontiersin.org
Phosphatidylserine (PS) is an anionic phospholipid in the eukaryotic membrane and is
abundant in the brain. Accumulated studies have revealed that PS is involved in the multiple …

Dementia in Africa: Current evidence, knowledge gaps, and future directions

RO Akinyemi, J Yaria, A Ojagbemi… - Alzheimer's & …, 2022 - Wiley Online Library
In tandem with the ever‐increasing aging population in low and middle‐income countries,
the burden of dementia is rising on the African continent. Dementia prevalence varies from …