The maintenance of iron homeostasis is essential for proper cardiac function. A growing
body of evidence suggests that iron imbalance is the common denominator in many …

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Skin cutaneous melanoma (SKCM, hereafter referred to as melanoma) is the most lethal
skin cancer with increasing incidence. Regulated cell death plays an important role in …

The endothelium is a single layer of epithelium covering the surface of the vascular system,
and it represents a physical barrier between the blood and vessel wall that plays an …

Background Despite advances in early detection and therapies, cancer is still one of the
most common causes of death worldwide. Since each tumor is unique, there is a need to …

The removal of functionally dispensable, infected or potentially neoplastic cells is driven by
programmed cell death (PCD) pathways, highlighting their important roles in homeostasis …

Cell death is an important component of the pathophysiology of cardiovascular disease. An
understanding of how cardiomyocytes die, and why regeneration of cells in the heart is …

Metabolic enzymes have an indispensable role in metabolic reprogramming, and their
aberrant expression or activity has been associated with chemosensitivity. Hence, targeting …

Ischemic stroke represents a significant danger to human beings, especially the elderly.
Interventions are only available to remove the clot, and the mechanism of neuronal death …

Background: Myocardial ischemia-reperfusion (I/R) injury causes cardiac dysfunction to
myocardial cell loss and fibrosis. Prevention of cell death is important to protect cardiac …