The JAK-STAT pathway at 30: Much learned, much more to do
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
[HTML][HTML] JAKs and STATs from a clinical perspective: loss-of-function mutations, gain-of-function mutations, and their multidimensional consequences
N Ott, L Faletti, M Heeg, V Andreani… - Journal of Clinical …, 2023 - Springer
The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …
[PDF][PDF] Sensory neurons promote immune homeostasis in the lung
M Tamari, KL Del Bel, AM Ver Heul, L Zamidar… - Cell, 2024 - cell.com
Cytokines employ downstream Janus kinases (JAKs) to promote chronic inflammatory
diseases. JAK1-dependent type 2 cytokines drive allergic inflammation, and patients with …
diseases. JAK1-dependent type 2 cytokines drive allergic inflammation, and patients with …
[PDF][PDF] The ins and outs of innate and adaptive type 2 immunity
AB Molofsky, RM Locksley - Immunity, 2023 - cell.com
Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced by
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …
Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases
Type 2 inflammation is characterized by overexpression and heightened activity of type 2
cytokines, mediators and cells that drive neuroimmune activation and sensitization to …
cytokines, mediators and cells that drive neuroimmune activation and sensitization to …
Cytokine-mediated STAT-dependent pathways underpinning human B-cell differentiation and function
B cells are fundamental to host defence against infectious diseases; indeed, the ability of
humans to elicit robust antibody responses following exposure to foreign antigens underpins …
humans to elicit robust antibody responses following exposure to foreign antigens underpins …
The ups and downs of STAT3 function: too much, too little and human immune dysregulation
The STAT3 story has almost 30 years of evolving history. First identified in 1994 as a pro-
inflammatory transcription factor, Signal Transducer and Activator of Transcription 3 (STAT3) …
inflammatory transcription factor, Signal Transducer and Activator of Transcription 3 (STAT3) …
[HTML][HTML] Transcription factor defects in inborn errors of immunity with atopy
Transcription factors (TFs) are critical components involved in regulating immune system
development, maintenance, and function. Monogenic defects in certain TFs can therefore …
development, maintenance, and function. Monogenic defects in certain TFs can therefore …
Interplay between epigenetic and genetic alterations in inborn errors of immunity
J Rodríguez-Ubreva, CL Calvillo, LRF Satter… - Trends in …, 2023 - cell.com
Inborn errors of immunity (IEIs) comprise a variety of immune conditions leading to
infections, autoimmunity, allergy, and cancer. Some IEIs have no identified mutation (s) …
infections, autoimmunity, allergy, and cancer. Some IEIs have no identified mutation (s) …
T-helper-2 cells and atopic disease: lessons learnt from inborn errors of immunity
CS Ma - Current Opinion in Immunology, 2023 - Elsevier
Highlights•Interleukin (IL)-6/STAT3/ERBIN pathway retrains human Th2 cells.•IFNγ, but not
IL-12, is a negative regulator of human Th2 cell development.•STAT6 is a key driver of Th2 …
IL-12, is a negative regulator of human Th2 cell development.•STAT6 is a key driver of Th2 …