The health effects of vitamin D supplementation: evidence from human studies

R Bouillon, D Manousaki, C Rosen… - Nature Reviews …, 2022 - nature.com
Vitamin D supplementation can prevent and cure nutritional rickets in infants and children.
Preclinical and observational data suggest that the vitamin D endocrine system has a wide …

The effects of vitamin D on immune system and inflammatory diseases

T Ao, J Kikuta, M Ishii - Biomolecules, 2021 - mdpi.com
Immune cells, including dendritic cells, macrophages, and T and B cells, express the vitamin
D receptor and 1α-hydroxylase. In vitro studies have shown that 1, 25-dihydroxyvitamin D …

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial

J Hahn, NR Cook, EK Alexander, S Friedman, J Walter… - Bmj, 2022 - bmj.com
Objective To investigate whether vitamin D and marine derived long chain omega 3 fatty
acids reduce autoimmune disease risk. Design Vitamin D and omega 3 trial (VITAL), a …

An update on the effects of vitamin D on the immune system and autoimmune diseases

C Sîrbe, S Rednic, A Grama, TL Pop - International journal of molecular …, 2022 - mdpi.com
Vitamin D intervenes in calcium and phosphate metabolism and bone homeostasis.
Experimental studies have shown that 1, 25-dihydroxyvitamin D (calcitriol) generates …

[HTML][HTML] COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality rate close to zero could theoretically be achieved at 50 ng/mL 25 (OH) D3 …

L Borsche, B Glauner, J von Mendel - Nutrients, 2021 - mdpi.com
Background: Open Access Editor's Choice Systematic Review COVID-19 Mortality Risk
Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could …

Molecular and cellular heterogeneity in rheumatoid arthritis: mechanisms and clinical implications

J Zhao, S Guo, SJ Schrodi, D He - Frontiers in immunology, 2021 - frontiersin.org
Rheumatoid arthritis is an autoimmune disease that exhibits significant clinical
heterogeneity. There are various treatments for rheumatoid arthritis, including disease …

Vitamin D modulates intestinal microbiota in inflammatory bowel diseases

C Battistini, R Ballan, ME Herkenhoff… - International journal of …, 2020 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract (GIT),
including Crohn's disease (CD) and ulcerative colitis (UC), which differ in the location and …

The role of vitamin D in health and disease: A narrative review on the mechanisms linking vitamin D with disease and the effects of supplementation

E Rebelos, N Tentolouris, E Jude - Drugs, 2023 - Springer
Vitamin D insufficiency or deficiency (VDD) is a very prevalent condition in the general
population. Vitamin D is necessary for optimal bone mineralization, but apart from the bone …

Comparing the evidence from observational studies and randomized controlled trials for nonskeletal health effects of vitamin D

WB Grant, BJ Boucher, F Al Anouti, S Pilz - Nutrients, 2022 - mdpi.com
Although observational studies of health outcomes generally suggest beneficial effects with,
or following, higher serum 25-hydroxyvitamin D [25 (OH) D] concentrations, randomized …

Metabolic reprogramming of the intestinal microbiome with functional bile acid changes underlie the development of NAFLD

E Smirnova, MD Muthiah, N Narayan, MS Siddiqui… - Hepatology, 2022 - journals.lww.com
Autoimmune hepatitis (AIH) is a rare disease of unclear etiology characterized by loss of self‐
tolerance that can lead to liver injury, cirrhosis, and acute liver failure. First‐line treatment …