For the past 30 years, improvements in the survival of patients with osteosarcoma have been
mostly incremental. Despite evidence of genomic instability and a high frequency of …

Osteoarthritis (OA) is a progressive and disabling musculoskeletal disease affecting millions
of people and resulting in major healthcare costs worldwide. It is the most common form of …

Simple Summary Bone is an extremely metabolically active tissue that is regenerated and
repaired over its lifetime by bone remodeling. Most bone diseases are caused by abnormal …

Emerging evidence indicates that microRNAs (miRNAs) play essential roles in regulating
osteoblastogenesis and bone formation. However, the role of miRNA in osteoblast …

Recent evidence demonstrating an increased fracture risk among obese individuals
suggests that adipose tissue may negatively impact bone health, challenging the traditional …

Context: The conventional view that obesity is beneficial for bone strength has recently been
challenged by studies that link obesity, particularly visceral obesity, to low bone mass and …

Osteoblasts are key components of the bone multicellular unit and have a seminal role in
bone remodeling, which is an essential function for the maintenance of the structural …

Osteocytes, entrapped within a newly mineralized bone matrix, possess a unique cellular
identity due to a specialized morphology and a molecular signature. These features endow …

Osteocytes are cells buried in the bone matrix. They largely contribute to the regulation of
bone remodeling in response to mechanical and microenvironmental changes. Much has …

Objectives To determine if running biomechanics and bone mineral density (BMD) were
independently associated with bone stress injury (BSI) in a cohort of National Collegiate …