The molecular basis for load-induced skeletal muscle hypertrophy

GR Marcotte, DWD West, K Baar - Calcified tissue international, 2015 - Springer
In a mature (weight neutral) animal, an increase in muscle mass only occurs when the
muscle is loaded sufficiently to cause an increase in myofibrillar protein balance. A tight …

Micromotion-induced strain fields influence early stages of repair at bone–implant interfaces

RM Wazen, JA Currey, H Guo, JB Brunski, JA Helms… - Acta biomaterialia, 2013 - Elsevier
Implant loading can create micromotion at the bone–implant interface. The interfacial strain
associated with implant micromotion could contribute to regulating the tissue healing …

Osteocyte morphology in human tibiae of different bone pathologies with different bone mineral density—is there a role for mechanosensing?

RP van Hove, PA Nolte, A Vatsa, CM Semeins… - Bone, 2009 - Elsevier
Matrix strains due to external loading are different in bones of different pathologies with
different bone mineral density (BMD), and are likely sensed by the osteocytes, the putative …

Scaffold pore curvature influences ΜSC fate through differential cellular organization and YAP/TAZ activity

WB Swanson, M Omi, SM Woodbury… - International journal of …, 2022 - mdpi.com
Tissue engineering aims to repair, restore, and/or replace tissues in the human body as an
alternative to grafts and prostheses. Biomaterial scaffolds can be utilized to provide a three …

[HTML][HTML] Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration

P Zhang, X Liu, P Guo, X Li, Z He, Z Li, MJ Stoddart… - Bioactive materials, 2021 - Elsevier
It has been proven that the mechanical microenvironment can impact the differentiation of
mesenchymal stem cells (MSCs). However, the effect of mechanical stimuli in biofabricating …

Controlled differentiation of human bone marrow stromal cells using magnetic nanoparticle technology

JM Kanczler, HS Sura, J Magnay, D Green… - … engineering Part A, 2010 - liebertpub.com
Targeting and differentiating stem cells at sites of injury and repair is an exciting and
promising area for disease treatment and reparative medicine. We have investigated remote …

Mouse tail vertebrae adapt to cyclic mechanical loading by increasing bone formation rate and decreasing bone resorption rate as shown by time-lapsed in vivo …

FM Lambers, FA Schulte, G Kuhn, DJ Webster… - Bone, 2011 - Elsevier
It is known that mechanical loading leads to an increase in bone mass through a positive
shift in the balance between bone formation and bone resorption. How the remodeling sites …

Exercise and bone mineral density in premenopausal women: a meta‐analysis of randomized controlled trials

GA Kelley, KS Kelley, WM Kohrt - International journal of …, 2013 - Wiley Online Library
Objective. Examine the effects of exercise on femoral neck (FN) and lumbar spine (LS) bone
mineral density (BMD) in premenopausal women. Methods. Meta‐analysis of randomized …

Optimal mechanical environment of the healing bone fracture/osteotomy

B Mavčič, V Antolič - International orthopaedics, 2012 - Springer
The aim of this paper is to review recent experimental and clinical publications on bone
biology with respect to the optimal mechanical environment in the healing process of …

[HTML][HTML] Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice

Z Xiao, M Dallas, N Qiu, D Nicolella, L Cao… - The FASEB …, 2011 - ncbi.nlm.nih.gov
We investigated whether polycystin-1 is a bone mechanosensor. We conditionally deleted
Pkd1 in mature osteoblasts/osteocytes by crossing Dmp1-Cre with Pkd1 flox/m1Bei mice, in …