[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

[HTML][HTML] Polysaccharides and their derivatives as potential antiviral molecules

H Claus-Desbonnet, E Nikly, V Nalbantova… - Viruses, 2022 - mdpi.com
In the current context of the COVID-19 pandemic, it appears that our scientific resources and
the medical community are not sufficiently developed to combat rapid viral spread all over …

[HTML][HTML] Trends in the disease burden of HBV and HCV infection in China from 1990-2019

T Yue, Q Zhang, T Cai, M Xu, H Zhu… - International Journal of …, 2022 - Elsevier
Objectives This study aimed to reveal the 30-year dynamics of hepatitis B virus (HBV) and
hepatitis C virus (HCV) disease burden in China from 1990-2019. Methods HBV/HCV data …

[HTML][HTML] Antiretroviral treatment of HIV-2 infection: available drugs, resistance pathways, and promising new compounds

I Moranguinho, N Taveira, I Bártolo - International Journal of Molecular …, 2023 - mdpi.com
Currently, it is estimated that 1–2 million people worldwide are infected with HIV-2,
accounting for 3–5% of the global burden of HIV. The course of HIV-2 infection is longer …

[HTML][HTML] Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19

X Jing, M Xu, D Song, T Yue, Y Wang, P Zhang… - Immunity & …, 2022 - Springer
Background COVID-19 patients may experience “cytokine storm” when human immune
system produces excessive cytokines/chemokines. However, it remains unclear whether …

Biktarvy for the treatment of HIV infection: Progress and prospects

E De Clercq, Z Zhang, J Huang, M Zhang… - Biochemical Pharmacology, 2023 - Elsevier
Abstract Bictegravir (BIC), a second-generation integrase strand-transfer inhibitor (INSTI)
with high resilience to INSTI-resistance mutations, is integrated as a key component of …

Targeting ribonucleases with small molecules and bifunctional molecules

L Borgelt, P Wu - ACS Chemical Biology, 2023 - ACS Publications
Ribonucleases (RNases) cleave and process RNAs, thereby regulating the biogenesis,
metabolism, and degradation of coding and noncoding RNAs. Thus, small molecules …

[HTML][HTML] Nicotinamide mononucleotide impacts HIV-1 infection by modulating immune activation in T lymphocytes and humanized mice

Y Mo, M Yue, LY Yim, R Zhou, C Yu, Q Peng, Y Zhou… - …, 2023 - thelancet.com
Background HIV-1-associated immune activation drives CD4+ T cell depletion and the
development of acquired immunodeficiency syndrome. We aimed to determine the role of …

[HTML][HTML] Lactoferrin as a component of pharmaceutical preparations: An experimental focus

F Guzmán-Mejía, M Godínez-Victoria… - Pharmaceuticals, 2023 - mdpi.com
Lactoferrin is an 80 kDa monomeric glycoprotein that exhibits multitask activities. Lactoferrin
properties are of interest in the pharmaceutical field for the design of products with …

[HTML][HTML] Indole-based compounds as potential drug candidates for SARS-CoV-2

AS Girgis, SS Panda, BM Kariuki, MS Bekheit… - Molecules, 2023 - mdpi.com
The COVID-19 pandemic has posed a significant threat to society in recent times,
endangering human health, life, and economic well-being. The disease quickly spreads due …