Do men die young and sick, or do women live long and healthy? By trying to explain the
sexual dimorphism in life expectancy, both biological and environmental aspects are …

As global life expectancy continues to rise, we are challenged with maintaining health into
old age. One strategy is to target the chronic low-level inflammation associated with aging …

Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological
age. Here, we use four such age estimators to show that epigenetic aging can be reversed …

As we age, the innate immune system becomes dysregulated and is characterized by
persistent inflammatory responses that involve multiple immune and non-immune cell types …

Sarcopenia is a progressive skeletal muscle disease that occurs most commonly in the
elderly population, contributing to increased costs and hospitalization. Exercise and …

Aging is associated with remodeling of the immune system to enable the maintenance of life-
long immunity. In the CD8+ T cell compartment, aging results in the expansion of highly …

It is widely accepted that the brain and the immune system continuously interact during
normal as well as pathological functioning. Human aging is commonly accompanied by low …

Age is associated with altered immune functions that may affect the brain. Brain barriers,
including the blood–brain barrier (BBB) and blood–CSF barrier (BCSFB), are important …

Chronic obstructive pulmonary disease (COPD) is regarded as a disease of accelerated
lung aging. This affliction shows all of the hallmarks of aging, including telomere shortening …

Chronic inflammation is the common pathological basis for such age-associated diseases
as cardiovascular disease, diabetes, cancer and Alzheimer's disease. A multitude of bodily …