Accelerating drug discovery via organs-on-chips
Considerable advances have been made in the development of micro-physiological
systems that seek to faithfully replicate the complexity and functionality of animal and human …
systems that seek to faithfully replicate the complexity and functionality of animal and human …
On-chip hydrogel arrays individually encapsulating acoustic formed multicellular aggregates for high throughput drug testing
X Hu, S Zhao, Z Luo, Y Zuo, F Wang, J Zhu, L Chen… - Lab on a Chip, 2020 - pubs.rsc.org
Multicellular aggregates in three-dimensional (3D) environments provide novel solid tumor
models that can provide insight into in vivo drug resistance. Such models are therefore …
models that can provide insight into in vivo drug resistance. Such models are therefore …
Cellular control of tissue architectures using a three-dimensional tissue fabrication technique
Tissue engineering seeks to provide regenerated tissue architectures in vitro but has not yet
successfully created thick, highly vascularized, multi-functional tissues replicating native …
successfully created thick, highly vascularized, multi-functional tissues replicating native …
Microfluidic devices as tools for mimicking the in vivo environment
K Ziółkowska, R Kwapiszewski, Z Brzózka - New Journal of Chemistry, 2011 - pubs.rsc.org
One of the major branches of microfluidic development is cell engineering. A number of
devices for cell cultivation, lysis, single-cell analysis and cell-based toxicity tests have been …
devices for cell cultivation, lysis, single-cell analysis and cell-based toxicity tests have been …
Synthetic hydrogels for controlled stem cell differentiation
Stem cells offer great promise for regenerative medicine because of their pluripotency and
their ability for self-renewal; however, their use in clinical treatments requires knowledge of …
their ability for self-renewal; however, their use in clinical treatments requires knowledge of …
[HTML][HTML] Surface acoustic waves grant superior spatial control of cells embedded in hydrogel fibers
By exploiting surface acoustic waves (SAWs) and a coupling layer technique, cells are
patterned within a photosensitive hydrogel fiber to mimic physiological cell arrangement in …
patterned within a photosensitive hydrogel fiber to mimic physiological cell arrangement in …
Integrated micro/nanoengineered functional biomaterials for cell mechanics and mechanobiology: a materials perspective
The rapid development of micro/nanoengineered functional biomaterials in the last two
decades has empowered materials scientists and bioengineers to precisely control different …
decades has empowered materials scientists and bioengineers to precisely control different …
Nanofiber enabled layer-by-layer approach toward three-dimensional tissue formation
Taking rapid and efficient formation of functional tissues as our long-term goal, we discuss in
this study a new and generic approach toward formation of multilayered three-dimensional …
this study a new and generic approach toward formation of multilayered three-dimensional …
The effect of culture conditions on the adipogenic and osteogenic inductions of mesenchymal stem cells on micropatterned surfaces
R Peng, X Yao, B Cao, J Tang, J Ding - Biomaterials, 2012 - Elsevier
Herein we examined an adipogenic or osteogenic induction of rat bone marrow
mesenchymal stem cells (MSCs) in the corresponding media and a co-induction in a 1: 1 …
mesenchymal stem cells (MSCs) in the corresponding media and a co-induction in a 1: 1 …
Alginate microencapsulation for three-dimensional in vitro cell culture
Advances in microscale 3D cell culture systems have helped to elucidate cellular
physiology, understand mechanisms of stem cell differentiation, produce pathophysiological …
physiology, understand mechanisms of stem cell differentiation, produce pathophysiological …