Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

The genomes of virtually all organisms contain repetitive sequences that are generated by
the activity of transposable elements (transposons). Transposons are mobile genetic …

All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …

The elderly may represent a specific cluster of high-risk patients for developing COVID-19
with rapidly progressive clinical deterioration. Indeed, in older individuals …

Biological aging involves an interplay of conserved and targetable molecular mechanisms,
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …

As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

Ageing is characterized by the functional decline of tissues and organs and the increased
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …

Chronic venous disease (CVD) is a multifactorial condition affecting an important
percentage of the global population. It ranges from mild clinical signs, such as …