Hemoperfusion: technical aspects and state of the art

C Ronco, R Bellomo - Critical care, 2022 - Springer
Background Blood purification through the removal of plasma solutes by adsorption to
beads of charcoal or resins contained in a cartridge (hemoperfusion) has a long and …

Efficacy of CytoSorb®: a systematic review and meta-analysis

S Becker, H Lang, C Vollmer Barbosa, Z Tian, A Melk… - Critical Care, 2023 - Springer
Introduction Cytokine adsorption using the CytoSorb® adsorber has been proposed in
various clinical settings including sepsis, ARDS, hyperinflammatory syndromes, cardiac …

Hemoperfusion in the intensive care unit

Z Ricci, S Romagnoli, T Reis, R Bellomo… - Intensive care medicine, 2022 - Springer
Multiple organ failure following a septic event derives from immune dysregulation. Many of
the mediators of this process are humoral factors (cytokines), which could theoretically be …

Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses

Y Li, Y Chen, T Yang, K Chang, N Deng, W Zhao, B Su - Critical Care, 2023 - Springer
Both high mobility group box-1 (HMGB1) and histones are major damage-associated
molecular patterns (DAPMs) that mediate lethal systemic inflammation, activation of the …

CytoSorb in patients with coronavirus disease 2019: A rapid evidence review and meta-analysis

S Wei, Y Zhang, K Zhai, J Li, M Li, J Yang… - Frontiers in …, 2023 - frontiersin.org
Background After its approval by the European Union in 2011, CytoSorb therapy has been
applied to control cytokine storm and lower the increased levels of cytokines and other …

Advances in attractive therapeutic approach for macrophage activation syndrome in COVID-19

S Chen, C Zhang, D Chen, L Dong, T Chang… - Frontiers in …, 2023 - frontiersin.org
Nowadays, people have relaxed their vigilance against COVID-19 due to its declining
infection numbers and attenuated virulence. However, COVID-19 still needs to be concern …

Effect of extracorporeal hemoadsorption in critically ill patients with COVID-19: A narrative review

K Chang, Y Li, Z Qin, Z Zhang, L Wang… - Frontiers in …, 2023 - frontiersin.org
COVID-19 has been affecting the world unprecedentedly and will remain widely prevalent
due to its elusive pathophysiological mechanism and the continuous emergence of new …

Blood purification in sepsis and COVID-19: what´ s new in cytokine and endotoxin hemoadsorption

JC Ruiz-Rodríguez, EP Plata-Menchaca… - Journal of Anesthesia …, 2022 - Springer
Sepsis and COVID-19 are two clinical conditions that can lead to a dysregulated
inflammatory state causing multiorgan dysfunction, hypercytokinemia, and a high risk of …

A new ex‐situ machine perfusion device. A preliminary evaluation using a model of donors after circulatory death pig livers

D Ghinolfi, F Melandro, D Patrono, Q Lai… - Artificial …, 2022 - Wiley Online Library
We herein describe a new ex‐situ machine perfusion device as a “technology spotlight”
using a model of donors after circulatory death liver grafts procured from slaughterhouse …

Impact of CytoSorb® on interleukin-6 in cardiac surgery

D Geisler, N Arleth, J Grabenwöger, Z Arnold… - Frontiers in …, 2023 - frontiersin.org
Objective Cardiac surgery is known to activate a cascade of inflammatory mediators leading
to a systemic inflammatory response. Hemadsorption (HA) devices such as CytoSorb® have …