Hepatic encephalopathy (HE) is a frequent and serious complication of both chronic liver
disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric …

According to a recent World Health Organization estimate, the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) pandemic, which originated in China in 2019, has …

The natural history of cirrhosis is characterised by an asymptomatic compensated phase
followed by a decompensated phase, marked by the development of overt clinical signs, the …

Cirrhosis is widely prevalent worldwide and can be a consequence of different causes, such
as obesity, non-alcoholic fatty liver disease, high alcohol consumption, hepatitis B or C …

The harmful use of alcohol has been estimated to cause approximately 3.3 million deaths
every year, corresponding to nearly 6% of all deaths globally. Therefore, the effective …

Macrophages represent a key cellular component of the liver, and are essential for
maintaining tissue homeostasis and ensuring rapid responses to hepatic injury. Our …

Background & Aims Bacterial infections are common and life-threatening in patients with
cirrhosis. Little is known about the epidemiology of bacterial infections in different regions …

Our view on liver macrophages in the context of health and disease has been reformed by
the recognition of a remarkable heterogeneity of phagocytes in the liver. Liver macrophages …

Hepatocellular carcinoma (HCC) is the third leading cause of worldwide cancer mortality.
HCC almost exclusively develops in patients with chronic liver disease, driven by a vicious …

There is a universal agreement that the occurrence of clinical complications, such as ascites,
hepatic encephalopathy, gastrointestinal bleeding, and jaundice mark the transition from the …