The intestine contains the largest microbial community in the human body, the gut
microbiome. Increasing evidence suggests that it plays a crucial role in maintaining overall …

The human microbiome orchestrates a variety of metabolic, immunological and regulatory
functions in health and disease. However, experimentally dissecting host–microbiome …

To protect the body from external pathogens, the intestines have sophisticated epithelial and
mucosal barriers. Disruptions to barrier integrity are associated with a variety of disorders …

Bacteriotherapy represents an attractive approach for both prophylaxis and treatment of
human diseases. However, combining probiotic bacteria in “cocktails” is underexplored …

The continued rise in metabolic diseases such as obesity and type 2 diabetes mellitus poses
a global health burden, necessitating further research into factors implicated in the onset …

The pathophysiological regulatory mechanisms in postoperative neurocognitive disorders
(PNCDs) are intricately complex. Currently, the pathogenesis of PNCDs has not been fully …

Enterohemorrhagic Escherichia coli (EHEC) is a critical public health concern due to its role
in severe gastrointestinal illnesses in humans, including hemorrhagic colitis and the life …

Introduction There is a growing need for alternative models to advance current non-clinical
experimental models because they often fail to accurately predict drug responses in clinical …

Background Emerging evidence underscores the responsiveness of the mammalian
intestine to dietary cues, notably through the involvement of LGR5+ intestinal stem cells in …

Inflammatory bowel disease (IBD), celiac disease, and other inflammatory conditions of the
gastrointestinal tract are highly prevalent in society. Due to the complexity of factors …