Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the
loss or failure of an organ or tissue, with the aim to restore the dysfunctional tissues and …

Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …

Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …

Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …

The remarkable anatomical homeostasis exhibited by complex living organisms suggests
that they are inherently reprogrammable information-processing systems that offer …

Physical activity has been known as an essential element to promote human health for
centuries. Thus, exercise intervention is encouraged to battle against sedentary lifestyle …

The regenerative function of liver can be destroyed by viral infection, drug poisoning and
tumorigenesis, resulting in irreversible damage. Numerous approaches in promoting liver …

The liver can fully regenerate after partial resection, and its underlying mechanisms have
been extensively studied. The liver can also rapidly regenerate after injury, with most studies …

The conclusive identity of Wnts regulating liver zonation (LZ) and regeneration (LR) remains
unclear despite an undisputed role of β-catenin. Using single-cell analysis, we identified a …

Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned
after birth. A multinodular network of transcription factors, along with pre-mRNA splicing …