[HTML][HTML] Non-alcoholic fatty liver disease as a canonical example of metabolic inflammatory-based liver disease showing a sex-specific prevalence: relevance of …

S Della Torre - Frontiers in endocrinology, 2020 - frontiersin.org
There is extensive evidence supporting the interplay between metabolism and immune
response, that have evolved in close relationship, sharing regulatory molecules and …

[HTML][HTML] Ectopic fat accumulation in distinct insulin resistant phenotypes; targets for personalized nutritional interventions

I Trouwborst, SM Bowser, GH Goossens… - Frontiers in …, 2018 - frontiersin.org
Cardiometabolic diseases are one of the leading causes for disability and mortality in the
Western world. The prevalence of these chronic diseases is expected to rise even further in …

[HTML][HTML] Potential therapeutic application of estrogen in gender disparity of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

C Lee, J Kim, Y Jung - Cells, 2019 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) caused by fat accumulation in the liver is globally
the most common cause of chronic liver disease. Simple steatosis can progress to …

Reproductive endocrinology of nonalcoholic fatty liver disease

M Grossmann, ME Wierman, P Angus… - Endocrine …, 2019 - academic.oup.com
The liver and the reproductive system interact in a multifaceted bidirectional fashion. Sex
steroid signaling influences hepatic endobiotic and xenobiotic metabolism and contributes …

[HTML][HTML] Role of steroid hormones in the pathogenesis of nonalcoholic fatty liver disease

M Yang, F Ma, M Guan - Metabolites, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
and may progress to cirrhosis or even hepatocellular carcinoma. A number of steroid …

[HTML][HTML] 40 YEARS of IGF1: Understanding the tissue-specific roles of IGF1/IGF1R in regulating metabolism using the Cre/loxP system

RD Kineman, M del Rio-Moreno… - Journal of molecular …, 2018 - jme.bioscientifica.com
It is clear that insulin-like growth factor-1 (IGF1) is important in supporting growth and
regulating metabolism. The IGF1 found in the circulation is primarily produced by the liver …

Fatty liver index and development of cardiovascular disease: findings from the UK biobank

B Zou, YH Yeo, R Cheung, E Ingelsson… - Digestive Diseases and …, 2021 - Springer
Background Nonalcoholic fatty liver disease is common and is associated with rising
morbidity and mortality in the UK. Cardiovascular disease is the main cause of death in …

[HTML][HTML] Changes in m6A in steatotic liver disease

BJ Petri, MC Cave, CM Klinge - Genes, 2023 - mdpi.com
Fatty liver disease is one of the major causes of morbidity and mortality worldwide. Fatty liver
includes non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis …

[HTML][HTML] Estrogen deficiency promotes hepatic steatosis via a glucocorticoid receptor-dependent mechanism in mice

MA Quinn, X Xu, M Ronfani, JA Cidlowski - Cell reports, 2018 - cell.com
Glucocorticoids (GCs) are master regulators of systemic metabolism. Intriguingly, Cushing's
syndrome, a disorder of excessive GCs, phenocopies several menopause-induced …

Diabetes mellitus in breast cancer survivors: metabolic effects of endocrine therapy

NS Thomas, RL Scalzo, EA Wellberg - Nature Reviews Endocrinology, 2024 - nature.com
Breast cancer is the most common invasive malignancy in the world, with millions of
survivors living today. Type 2 diabetes mellitus (T2DM) is also a globally prevalent disease …