Angiopoietins 1–4 (Ang1–4) represent an important family of growth factors, whose activities
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …

The lymphatic system, composed of initial and collecting lymphatic vessels as well as lymph
nodes that are present in almost every tissue of the human body, acts as an essential …

Lymphatic vessels maintain tissue fluid homeostasis by returning to blood circulation
interstitial fluid that has extravasated from the blood capillaries. They provide a trafficking …

The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF
receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human …

Sepsis accounts for nearly 700 000 deaths in Europe annually and is caused by an
overwhelming host response to infection resulting in organ failure. The endothelium is an …

The mammalian circulatory system comprises both the cardiovascular system and the
lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a …

Angiogenesis and lymphangiogenesis often occur in response to tissue injury or in the
presence of pathology (eg, cancer), and it is these types of environments in which …

Excess dietary lipid uptake causes obesity, a major global health problem. Enterocyte-
absorbed lipids are packaged into chylomicrons, which enter the bloodstream through …