Primary liver cancer (PLC) is the fourth most frequent cause of cancer-related death. The
high mortality rates arise from late diagnosis and the limited accuracy of diagnostic and …

Lysophosphatidylcholines are a group of bioactive lipids heavily investigated in the context
of inflammation and atherosclerosis development. While present in plasma during …

Precision medicine (PM) means the customization of healthcare with decisions and
practices adjusted to the individual patient. It includes personalized diagnostics, patients' …

Objective PD-1 inhibitors have improved efficacy in many cancers. There are currently no
reports of the use of PD-1 inhibitors, such as nivolumab, for metastatic biliary tract cancer …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal
cancers, with a 5-year survival rate of less than 5%. In fact, complete surgical resection …

Background/aims The papillomacular bundle (PMB) area is an important anatomical site
associated with central vision. As preventive medicine and health screening examinations …

The pathogenesis of pancreatic cancer involves substantial metabolic reprogramming,
resulting in abnormal proliferation of tumor cells. This tumorigenic reprogramming is often …

Diagnosing leptomeningeal metastasis (LM) in medulloblastoma is currently based on
positive cerebrospinal fluid (CSF) cytology or magnetic resonance imaging (MRI) finding …

Ovarian cancer is a common gynecologic cancer with high mortality but unclear molecular
mechanism. Most ovarian cancers are diagnosed in the advanced stage, which seriously …

Two years ago, writing a thesis was unknown territory for me. I was lucky to have the
enthusiastic guidance of my supervisor, Prof. Dr. Lennart Martens. He directed me in the …