Molecular and therapeutic advancements in Capicua (CIC)-rearranged sarcoma
RKM Ponce, C Luck, RA Okimoto - Frontiers in Cell and …, 2024 - frontiersin.org
Capicua (CIC)-rearranged sarcomas are an aggressive subset of undifferentiated round cell
sarcomas. CIC:: DUX4, the proto-typical CIC fusion oncoprotein is associated with rapid …
sarcomas. CIC:: DUX4, the proto-typical CIC fusion oncoprotein is associated with rapid …
Interaction network of human early embryonic transcription factors
L Gawriyski, Z Tan, X Liu, I Chowdhury… - EMBO …, 2024 - embopress.org
Embryonic genome activation (EGA) occurs during preimplantation development and is
characterized by the initiation of de novo transcription from the embryonic genome. Despite …
characterized by the initiation of de novo transcription from the embryonic genome. Despite …
LEUTX regulates porcine embryonic genome activation in somatic cell nuclear transfer embryos
K Zhou, T Wang, J Zhang, J Zhang, X Liu, J Guan, P Su… - Cell Reports, 2024 - cell.com
Emerging evidence highlights the regulatory role of paired-like (PRD-like) homeobox
transcription factors (TFs) in embryonic genome activation (EGA). However, the majority of …
transcription factors (TFs) in embryonic genome activation (EGA). However, the majority of …
Small blue round cell tumor with focal epithelial differentiation harboring a novel YAP1:: LEUTX fusion with poor prognosis
XX Yang, F Gao, R Ding, J Wei, XM Zhu, QX Gong - Virchows Archiv, 2024 - Springer
While the small blue round cell tumor encompasses a group of malignancies with varying
origins of differentiation, recent molecular genetic advancements have enabled a more …
origins of differentiation, recent molecular genetic advancements have enabled a more …
Longitudinal profiling of human androgenotes through single-cell analysis unveils paternal gene expression dynamics in early embryo development
X Vendrell, P de Castro, L Escrich, N Grau… - Human …, 2024 - academic.oup.com
STUDY QUESTION How do transcriptomics vary in haploid human androgenote embryos at
single cell level in the first four cell cycles of embryo development? SUMMARY ANSWER …
single cell level in the first four cell cycles of embryo development? SUMMARY ANSWER …
Engineered FSHD mutations results in D4Z4 heterochromatin disruption and feedforward DUX4 network activation
X Kong, NV Nguyen, Y Li, JS Sakr, K Williams, S Sharifi… - Iscience, 2024 - cell.com
Facioscapulohumeral dystrophy (FSHD) is linked to contraction of D4Z4 repeats on
chromosome 4q with SMCHD1 mutations acting as a disease modifier. D4Z4 …
chromosome 4q with SMCHD1 mutations acting as a disease modifier. D4Z4 …