Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) primarily affect the
motor and frontotemporal areas of the brain, respectively. These disorders share clinical …

Resting-state functional magnetic resonance imaging (rs-fMRI), which measures the
spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal, is …

Heterozygous, loss-of-function mutations in the granulin gene (GRN) encoding progranulin
(PGRN) are a common cause of frontotemporal dementia (FTD). Homozygous GRN …

Chromosome instability (CIN) has been repeatedly associated with aging and progeroid
phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic …

Research and innovation are integral parts of the global response to dementia. Yet, the
Global status report on the public health response to dementia shows that despite some …

Neurodegenerative movement disorders (NMDs) are age‐dependent disorders that are
characterised by the degeneration and loss of neurons, typically accompanied by …

Introduction Recent studies suggest that both sex‐specific genetic risk factors and those
shared between dementia and stroke are involved in dementia pathogenesis. Methods We …

Neurodegenerative diseases are a group of disorders characterized by neuronal cell death
causing a variety of physical and mental problems. While these disorders can be …

The effect of Alzheimer's disease (AD) polygenic risk scores (PRS) on amyloid and tau
pathophysiology and neurodegeneration in cognitively unimpaired older adults is not known …

Approximately 40% of dementia cases could be prevented or delayed by modifiable risk
factors related to lifestyle and environment. These risk factors, such as depression and …