[HTML][HTML] Engineered mesenchymal stem cell-derived extracellular vesicles: a state-of-the-art multifunctional weapon against Alzheimer's disease

T Yin, Y Liu, W Ji, J Zhuang, X Chen, B Gong, J Chu… - Theranostics, 2023 - ncbi.nlm.nih.gov
With the increase of population aging, the number of Alzheimer's disease (AD) patients is
also increasing. According to current estimates, approximately 11% of people over 65 suffer …

[HTML][HTML] Engineered EVs designed to target diseases of the CNS

L Nieland, S Mahjoum, E Grandell, K Breyne… - Journal of Controlled …, 2023 - Elsevier
Diseases of the central nervous system (CNS) are challenging to treat, mainly due to the
blood-brain barrier (BBB), which restricts drugs in circulation from entering target regions in …

Current and future directions of drug delivery for the treatment of mental illnesses

PR Brewster, SMI Bari, GM Walker, TA Werfel - Advanced Drug Delivery …, 2023 - Elsevier
Mental illnesses including anxiety disorders, autism spectrum disorder, post-traumatic stress
disorder, schizophrenia, depression, and others exact an immense toll on the healthcare …

Cell membrane-based nanomaterials for therapeutics of neurodegenerative diseases

PT Nguyen-Thi, TT Nguyen, HL Phan, TT Ho… - Neurochemistry …, 2023 - Elsevier
Central nervous system (CNS) diseases such as Alzheimer's disease (AD), Parkinson's
disease (PD), glioblastoma (GBM), and peripheral nerve injury have been documented as …

[HTML][HTML] Extracellular vesicles and their cells of origin: Open issues in autoimmune diseases

A Haghighitalab, M Dominici, MM Matin… - Frontiers in …, 2023 - frontiersin.org
The conventional therapeutic approaches to treat autoimmune diseases through
suppressing the immune system, such as steroidal and non-steroidal anti-inflammatory …

CRISPR/Cas9 delivery strategies with engineered extracellular vesicles

Y Lu, K Godbout, G Lamothe, JP Tremblay - Molecular Therapy-Nucleic …, 2023 - cell.com
Therapeutic genome editing has the potential to cure diseases by directly correcting genetic
mutations in tissues and cells. Recent progress in the clustered regularly interspaced short …

[HTML][HTML] Exosomes derived from mesenchymal stem cells: novel effects in the treatment of ischemic stroke

Y Xiong, J Song, X Huang, Z Pan… - Frontiers in …, 2022 - frontiersin.org
Ischemic stroke is defined as an infarction in the brain, caused by impaired cerebral blood
supply, leading to local brain tissue ischemia, hypoxic necrosis, and corresponding …

Nanotechnology-inspired extracellular vesicles theranostics for diagnosis and therapy of central nervous system diseases

T Tian, S Qiao, BA Tannous - ACS Applied Materials & Interfaces, 2022 - ACS Publications
Shuttling various bioactive substances across the blood–brain barrier (BBB) bidirectionally,
extracellular vesicles (EVs) have been opening new frontiers for the diagnosis and therapy …

[HTML][HTML] Transferrin-conjugated melittin-loaded l-arginine-coated iron oxide nanoparticles for mitigating beta-amyloid pathology of the 5XFAD mouse brain

M Choi, J Ryu, HD Vu, D Kim, YJ Youn… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases and a
major contributor to dementia. Although the cause of this condition has been identified long …

Dietary protective potential of fucoxanthin as an active food component on neurological disorders

Y Chen, H Lu, Y Ding, S Liu, Y Ding, B Lu… - Journal of Agricultural …, 2023 - ACS Publications
The prevalence of neurodegenerative, cerebrovascular, and psychiatric diseases and other
neurological disorders has increased dramatically worldwide. Fucoxanthin is an algal …