The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

Obesity is a chronic multisystem disease associated with increased morbidity and mortality.
The increasing prevalence of obesity makes it a major healthcare challenge across both …

Hypertension affects approximately one third of the world's adult population and is a major
cause of premature death despite considerable advances in pharmacological treatments …

Excessive adiposity raises blood pressure and accounts for 65–75% of primary
hypertension, which is a major driver of cardiovascular and kidney diseases. In obesity …

Background Over the past 20 years, insights from human and mouse genetics have
illuminated the central role of the brain leptin-melanocortin pathway in the control of …

Excess weight gain, especially when associated with increased visceral adiposity, is a major
cause of hypertension, accounting for 65% to 75% of the risk for human primary (essential) …

The prevalence of obesity-related glomerulopathy is increasing in parallel with the
worldwide obesity epidemic. Glomerular hypertrophy and adaptive focal segmental …

Patients with rare defects in the gene encoding proopiomelanocortin (POMC) have extreme
early-onset obesity, hyperphagia, hypopigmentation, and hypocortisolism, resulting from the …

Several articles have dealt with the importance and mechanisms of the sympathetic nervous
system alterations in experimental animal models of hypertension. This review addresses …

Background The melanocortin 4 receptor (MC4R), a component of the leptin–melanocortin
pathway, plays a part in bodyweight regulation. Severe early-onset obesity can be caused …