The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

Abstract Introduction The protein Klotho (KL) was first discovered in KL-deficient mice, which
developed a syndrome similar to premature aging in humans. Since then, KL has been …

Cardiovascular disease is the leading cause of death in patients with chronic kidney disease
(CKD). As CKD progresses, CKD-specific risk factors, such as disordered mineral …

Objective Accumulating experimental evidence has identified the beneficial effects of the
anti-aging protein, serum soluble α-Klotho, on longevity, and the cardiovascular system …

Initially discovered by Makuto Kuro-o in 1997, Klotho is a putative aging-suppressor gene
when overexpressed and accelerates aging when deleted in mice. Previously, we showed …

Background and aim Klotho was first identified as a gene associated with aging and
longevity in 1997. α-Klotho is an anti-aging protein and its role in energy metabolism …

Background Klotho has both anticancer and hormone‐like functions. But the research on
Klotho and cancer is mainly based on animal experiments and small‐scale clinical research …

Klotho, a multifunctional protein, acts as a co-receptor in fibroblast growth factor 23 and
exerts its impact through various molecular pathways, including Wnt, hypoxia-inducible …

Background Klotho is a hormone that emerges as an antiaging biomarker. However, the
influence of the dietary pattern's inflammatory potential on serum Klotho levels in human …

Introduction Studies on association of α-klotho levels with mortality risk in general population
are relatively scarce and inconclusive. Therefore, we conducted a population-based cohort …