Ferroptosis: machinery and regulation

X Chen, J Li, R Kang, DJ Klionsky, D Tang - Autophagy, 2021 - Taylor & Francis
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …

On iron metabolism and its regulation

ACS Vogt, T Arsiwala, M Mohsen, M Vogel… - International journal of …, 2021 - mdpi.com
Iron is a critical metal for several vital biological processes. Most of the body's iron is bound
to hemoglobin in erythrocytes. Iron from senescent red blood cells is recycled by …

Mitochondria and microbiota dysfunction in COVID-19 pathogenesis

J Saleh, C Peyssonnaux, KK Singh, M Edeas - Mitochondrion, 2020 - Elsevier
The COVID-19 pandemic caused by the coronavirus (SARS-CoV-2) has taken the world by
surprise into a major crisis of overwhelming morbidity and mortality. This highly infectious …

Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer

J Yang, Y Zhou, S Xie, J Wang, Z Li, L Chen… - Journal of Experimental …, 2021 - Springer
Background Ferroptosis is a newly defined form of regulated cell death characterized by the
iron-dependent accumulation of lipid peroxidation and is involved in various …

Ferroptosis: opportunities and challenges in myocardial ischemia‐reperfusion injury

W Zhao, Y Zhou, T Xu, Q Wu - Oxidative Medicine and Cellular …, 2021 - Wiley Online Library
Ferroptosis is a newly discovered form of regulated cell death dependent on iron and
reactive oxygen species (ROS). It directly or indirectly affects the activity of glutathione …

Simultaneous Fe2+/Fe3+ imaging shows Fe3+ over Fe2+ enrichment in Alzheimer's disease mouse brain

Y Wu, SF Torabi, RJ Lake, S Hong, Z Yu, P Wu… - Science …, 2023 - science.org
Visualizing redox-active metal ions, such as Fe2+ and Fe3+ ions, are essential for
understanding their roles in biological processes and human diseases. Despite the …

Ferroptosis: mechanisms and implications for cancer development and therapy response

AF Dos Santos, G Fazeli, TNX da Silva, JPF Angeli - Trends in cell biology, 2023 - cell.com
As cancer cells develop resistance to apoptosis, non-apoptotic cell death modalities, such
as ferroptosis, have emerged as promising strategies to combat therapy-resistant cancers …

Autophagy mediates an amplification loop during ferroptosis

S Lee, N Hwang, BG Seok, S Lee, SJ Lee… - Cell Death & …, 2023 - nature.com
Ferroptosis, a programmed cell death, has been identified and associated with cancer and
various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS) …

[HTML][HTML] A red carpet for iron metabolism

MU Muckenthaler, S Rivella, MW Hentze, B Galy - Cell, 2017 - cell.com
200 billion red blood cells (RBCs) are produced every day, requiring more than 2× 10 15
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …

The emerging role of ferroptosis in intestinal disease

S Xu, Y He, L Lin, P Chen, M Chen, S Zhang - Cell Death & Disease, 2021 - nature.com
Ferroptosis is a newly recognised type of regulated cell death (RCD) characterised by iron-
dependent accumulation of lipid peroxidation. It is significantly distinct from other RCDs at …