[HTML][HTML] Immune responses in mildly versus critically ill COVID-19 patients

H Nasrollahi, AG Talepoor, Z Saleh… - Frontiers in …, 2023 - frontiersin.org
The current coronavirus pandemic (COVID-19), caused by SARS-CoV-2, has had
devastating effects on the global health and economic system. The cellular and molecular …

Multi-omics blood atlas reveals unique features of immune and platelet responses to SARS-CoV-2 Omicron breakthrough infection

H Wang, C Liu, X Xie, M Niu, Y Wang, X Cheng… - Immunity, 2023 - cell.com
Although host responses to the ancestral SARS-CoV-2 strain are well described, those to
the new Omicron variants are less resolved. We profiled the clinical phenomes …

[HTML][HTML] NK cell subsets and dysfunction during viral infection: a new avenue for therapeutics?

JC Bjorgen, JK Dick, R Cromarty, GT Hart… - Frontiers in …, 2023 - frontiersin.org
In the setting of viral challenge, natural killer (NK) cells play an important role as an early
immune responder against infection. During this response, significant changes in the NK cell …

[HTML][HTML] Early expansion of activated adaptive but also exhausted NK cells during acute severe SARS-CoV-2 infection

M Claus, N Pieris, D Urlaub, P Bröde… - Frontiers in Cellular …, 2023 - frontiersin.org
The analysis of immunological parameters during the course of a SARS-CoV-2 infection is of
great importance, both to identify diagnostic markers for the risk of a severe course of COVID …

[HTML][HTML] Crosstalk between Platelets and SARS-CoV-2: Implications in Thrombo-Inflammatory Complications in COVID-19

J Zhao, X Xu, Y Gao, Y Yu, C Li - International Journal of Molecular …, 2023 - mdpi.com
The SARS-CoV-2 virus, causing the devastating COVID-19 pandemic, has been reported to
affect platelets and cause increased thrombotic events, hinting at the possible bidirectional …

[HTML][HTML] Systems analysis of human innate immunity in COVID-19

S Müller, JL Schultze - Seminars in immunology, 2023 - Elsevier
Recent developments in sequencing technologies, the computer and data sciences, as well
as increasingly high-throughput immunological measurements have made it possible to …

Low Percentage of Perforin-Expressing NK Cells during Severe SARS-CoV-2 Infection: Consumption Rather than Primary Deficiency

L Kundura, R Cezar, E Ballongue, S André… - The Journal of …, 2024 - journals.aai.org
Study design All patients were diagnosed as being SARS-CoV-2-infected by RT-PCR. Their
blood was drawn on the first day of hospitalization at an intensive care unit (ICU) or a non …

[HTML][HTML] Coordinated Loss and Acquisition of NK Cell Surface Markers Accompanied by Generalized Cytokine Dysregulation in COVID-19

MO Ustiuzhanina, JD Vavilova, AA Boyko… - International Journal of …, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, is accompanied
by a dysregulated immune response. In particular, NK cells, involved in the antiviral …

[HTML][HTML] The Ways of the Virus: Interactions of Platelets and Red Blood Cells with SARS-CoV-2, and Their Potential Pathophysiological Significance in COVID-19

MA Panteleev, AN Sveshnikova… - International Journal of …, 2023 - mdpi.com
The hematological effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) are important in COVID-19 pathophysiology. However, the interactions of SARS-CoV-2 …

[HTML][HTML] Multiple-cohort study of the elderly to determine the immunological characteristics and pathogenic mechanisms of severe community-acquired pneumonia …

T Lu, Q Man, S Xia, X Liu, Y Yan, X Yu, Y Fu, W Liu… - Cell Discovery, 2023 - nature.com
Dear Editor, Low-virulence respiratory viruses can cause severe community-acquired
pneumonia (Sev-CAP) in the elderly whose susceptibility is correlated with age-related …