In both child and adult psychiatry, empirical evidence has now accrued to suggest that a
single dimension is able to measure a person's liability to mental disorder, comorbidity …

Nonalcoholic fatty liver disease (NAFLD) affects around a quarter of the global population,
paralleling worldwide increases in obesity and metabolic syndrome. NAFLD arises in the …

Recent studies proposed a general psychopathology factor underlying common
comorbidities among psychiatric disorders. However, its neurobiological mechanisms and …

Supported by recent human neuroimaging studies, the insula is re-emerging as an important
brain area not only in the physiological understanding of the brain, but also in pathological …

The idea that disturbances occurring early in brain development contribute to the
pathogenesis of schizophrenia, often referred to as the neurodevelopmental hypothesis, has …

Abstract The Integrative Psychiatric Research (iPSYCH) consortium has established a large
Danish population-based Case–Cohort sample (iPSYCH2012) aimed at unravelling the …

There is mounting evidence that seemingly diverse psychiatric disorders share genetic
etiology, but the biological substrates mediating this overlap are not well characterized. Here …

Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown,
and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the …

Despite evidence that deleterious variants in the same genes are implicated across multiple
neurodevelopmental and neuropsychiatric disorders, there has been considerable interest …

Mood and psychotic syndromes most often emerge during adolescence and young
adulthood, a period characterised by major physical and social change. Consequently, the …