The unique architecture of the mammalian lung is required for adaptation to air breathing at
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …

The imbalance between pro-and anti-inflammatory immune responses mediated by Th17
and Treg cells is deeply involved in the development and progression of inflammation in …

Lipopolysaccharide (LPS), the major outer surface membrane component of Gram-negative
bacteria, is one of the main etiological factors in the pathogenesis of several lung diseases …

Chronic obstructive pulmonary disease (COPD) is an intractable disease involving a sticky
mucus layer and nanoagents with mucus‐penetrating capability offer a new way to deliver …

Asthma and Chronic Obstructive Pulmonary Disease (COPD) are chronic obstructive
respiratory diseases characterized by airway obstruction, inflammation, and remodeling …

Multiple kinases play a critical role in orchestrating the chronic inflammation and structural
changes in the respiratory tract of patients with asthma and chronic obstructive pulmonary …

Chronic obstructive pulmonary disease (COPD) is caused by exposure to toxic particles,
such as coal fly ash (CFA), diesel-exhaust particle (DEP), and cigarette smoke (CS), leading …

Background: Interleukin (IL)-6 trans-signalling (IL-6TS) is emerging as a pathogenic
mechanism in chronic respiratory diseases; however, the drivers of IL-6TS in the airways …

A key signaling channel for the signal transduction of several crucial cytokines implicated in
sepsis is the JAK/STAT system. Once cytokines attach to the proper receptors, JAK kinases …

Cytokines are pivotal mediators of the immune response, and their coordinated expression
protects host tissue from excessive damage and oxidant stress. Nevertheless, the …