Background One year after the declaration of the coronavirus disease 2019 (COVID-19)
pandemic by the World Health Organization (WHO) and despite the implementation of …

Human challenge trials (HCTs) are a potential method to accelerate development of
vaccines and therapeutics. However, HCTs for COVID‐19 pose ethical and practical …

Notwithstanding the success of conventional field trials for vaccines against COVID-19,
human challenge trials (HCTs) that could obtain more information about these and about …

The world's first coronavirus disease 2019 human challenge trial using the D614G strain of
severe acute respiratory syndrome 2 (SARS-CoV-2) is underway in the United Kingdom …

The outbreak of a novel coronavirus pneumonia (COVID-19), wherein more than 200 million
people have been infected and millions have died, poses a great threat to achieving the …

Vaccination is a cornerstone of global public health. Although licensed vaccines are
generally extremely safe, both experimental and licensed vaccines are sometimes …

Early into COVID, human challenge trials were considered, but usually as alternatives to
conventional randomized controlled trials. Instead, assessment of authorized COVID …

Can we permissibly accelerate vaccine testing even if this increases risk to study
participants? During the COVID-19 pandemic, researchers, policymakers, and bioethicists …

RESEARCH during pandemics and epidemics can raise distinctive ethical questions and
lend special urgency to familiar questions. In many epidemics and pandemics, the high …

One year after the declaration of the COVID-19 pandemic by the World Health Organization
(WHO) and despite the implementation of mandatory physical barriers and social distancing …