The importance of nitrate reduction for oral health

BT Rosier, N Takahashi, E Zaura… - Journal of dental …, 2022 - journals.sagepub.com
Salivary glands concentrate plasma nitrate into saliva, leading to high nitrate concentrations
that can reach the millimolar range after a nitrate-rich vegetable meal. Whereas human cells …

Osteoimmunology in periodontitis: local proteins and compounds to alleviate periodontitis

K Sirisereephap, T Maekawa, H Tamura… - International Journal of …, 2022 - mdpi.com
Periodontitis is one of the most common oral diseases resulting in gingival inflammation and
tooth loss. Growing evidence indicates that it results from dysbiosis of the oral microbiome …

Oral microorganisms and biofilms: new insights to defeat the main etiologic factor of oral diseases

M Bertolini, RC Costa, VAR Barão, CC Villar… - Microorganisms, 2022 - mdpi.com
The oral cavity presents a highly diverse community of microorganisms due to the unique
environmental conditions for microbial adhesion and growth [1]. The range of habitats and …

Outer Membrane Vesicles From Fusobacterium nucleatum Switch M0-Like Macrophages Toward the M1 Phenotype to Destroy Periodontal Tissues in Mice

G Chen, Q Sun, QL Cai, HW Zhou - Frontiers in Microbiology, 2022 - frontiersin.org
Periodontitis is a chronic inflammatory oral disease that affects nearly 50% of all adults.
Fusobacterium nucleatum (F. nucleatum) is known to be involved in the formation and …

Nitrate and a nitrate-reducing Rothia aeria strain as potential prebiotic or synbiotic treatments for periodontitis

D Mazurel, M Carda-Diéguez, T Langenburg… - npj Biofilms and …, 2023 - nature.com
A few studies indicate that nitrate can reduce dysbiosis from a periodontitis point of view.
However, these experiments were performed on samples from healthy individuals, and it is …

Oral microbiome research on oral lichen planus: Current findings and perspectives

W Jung, S Jang - Biology, 2022 - mdpi.com
Simple Summary Oral lichen planus is a disease of the oral mucosa, which frequently affects
women aged 40 years or older. Though the T cell-mediated immune response is involved in …

Mechanical biofilm disruption causes microbial and immunological shifts in periodontitis patients

W Johnston, BT Rosier, A Artacho, M Paterson… - Scientific reports, 2021 - nature.com
Periodontitis is characterized by subgingival biofilm dysbiosis, inflammation and tissue
destruction. Current treatment involves mechanical biofilm disruption known as non-surgical …

Nitrate reduction capacity of the oral microbiota is impaired in periodontitis: potential implications for systemic nitric oxide availability

BT Rosier, W Johnston, M Carda-Diéguez… - International Journal of …, 2024 - nature.com
The reduction of nitrate to nitrite by the oral microbiota has been proposed to be important
for oral health and results in nitric oxide formation that can improve cardiometabolic …

Precision periodontal care: from omics discoveries to chairside diagnostics

N Bostanci, GN Belibasakis - Clinical Oral Investigations, 2023 - Springer
The interface of molecular science and technology is guiding the transformation of
personalized to precision healthcare. The application of proteomics, genomics …

Unraveling the effectiveness of antibiotics for peri‐implantitis treatment: A scoping review

M Feres, R Martins, JGS Souza… - … Implant Dentistry and …, 2023 - Wiley Online Library
Background Antibiotics are the most effective adjuncts in the treatment of periodontitis.
However, the benefits of these agents in treating peri‐implantitis are still debatable and …