Iron metabolism in ferroptosis

X Chen, C Yu, R Kang, D Tang - Frontiers in cell and developmental …, 2020 - frontiersin.org
Ferroptosis is a form of regulated cell death that is characterized by iron-dependent
oxidative damage and subsequent plasma membrane ruptures and the release of damage …

Targeting ferroptosis: pathological mechanism and treatment of ischemia‐reperfusion injury

X Li, N Ma, J Xu, Y Zhang, P Yang, X Su… - Oxidative Medicine …, 2021 - Wiley Online Library
Ischemia‐reperfusion (I/R) is a pathological process that occurs in many organs and
diseases. Reperfusion, recovery of blood flow, and reoxygenation often lead to reperfusion …

Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

M Jakaria, AA Belaidi, AI Bush… - Journal of …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

Chinese herbal medicine: Fighting SARS-CoV-2 infection on all fronts

Z Wang, L Yang - Journal of Ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance Severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infection causes coronavirus disease 2019 (COVID-19), a highly pathogenic virus …

Ferroptosis and its potential role in human diseases

C Han, Y Liu, R Dai, N Ismail, W Su, B Li - Frontiers in pharmacology, 2020 - frontiersin.org
Ferroptosis is a novel regulated cell death pattern discovered when studying the mechanism
of erastin-killing RAS mutant tumor cells in 2012. It is an iron-dependent programmed cell …

[HTML][HTML] Quercetin alleviates kainic acid-induced seizure by inhibiting the Nrf2-mediated ferroptosis pathway

R Xie, W Zhao, S Lowe, R Bentley, G Hu, H Mei… - Free Radical Biology …, 2022 - Elsevier
Background Epilepsy is one of the most common neurological disorders in childhood.
However, classical antiepileptic drugs are linked with drug toxicity and cognitive function …

Targeting ferroptosis against ischemia/reperfusion cardiac injury

J Lillo-Moya, C Rojas-Solé, D Muñoz-Salamanca… - Antioxidants, 2021 - mdpi.com
Ischemic heart disease is a leading cause of death worldwide. Primarily, ischemia causes
decreased oxygen supply, resulting in damage of the cardiac tissue. Naturally …

Pretreatment with Roxadustat (FG‐4592) Attenuates Folic Acid‐Induced Kidney Injury through Antiferroptosis via Akt/GSK‐3β/Nrf2 Pathway

X Li, Y Zou, J Xing, YY Fu, KY Wang… - Oxidative Medicine …, 2020 - Wiley Online Library
Folic acid‐(FA‐) induced kidney injury is characterized by the tubule damage due to the
disturbance of the antioxidant system and subsequent interstitial fibrosis. FG‐4592 is an …

Cepharanthine Attenuates Early Brain Injury after Subarachnoid Hemorrhage in Mice via Inhibiting 15‐Lipoxygenase‐1‐Mediated Microglia and Endothelial Cell …

S Gao, L Zhou, J Lu, Y Fang, H Wu… - Oxidative medicine …, 2022 - Wiley Online Library
Background. Ferroptosis is a newly identified form of programmed cell death caused by iron‐
dependent lipid peroxidation. Our study was designed to determine the expression patterns …

Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury

QS Li, YJ Jia - Neural Regeneration Research, 2023 - journals.lww.com
Ferroptosis, a new non-necrotizing programmed cell death (PCD), is driven by iron-
dependent phospholipid peroxidation. Ferroptosis plays a key role in secondary traumatic …