Liver cancer is the third leading cause of cancer death worldwide. Representing such a
dramatic impact on our lives, liver cancer is a significant public health concern. Sustainable …

Frequent p53 mutations (mutp53) not only abolish tumor suppressor capacities but confer
various gain-of-function (GOF) activities that impacts molecules and pathways now regarded …

Inactivation of the p53 tumor suppressor is a frequent event in tumorigenesis. In most cases,
the p53 gene is mutated, giving rise to a stable mutant protein whose accumulation is …

Liver cancers cause a high rate of death worldwide and hepatocellular carcinoma (HCC) is
considered as the most common primary liver cancer. HCC remains a challenging disease …

Purpose: Hepatocellular carcinoma (HCC) is a heterogeneous cancer with active Wnt
signaling. Underlying biologic mechanisms remain unclear and no drug targeting this …

Dysregulation of pleiotropic growth factors, receptors and their downstream signaling
pathway components represent a central protumorigenic principle in human …

Most mammalian genes generate messenger RNAs with variable untranslated regions
(UTRs) that are important post-transcriptional regulators. In cancer, shortening at 3′ UTR …

Background β-catenin mutations that constitutively activate the canonical Wnt signaling have
been observed in a subset of hepatocellular carcinomas (HCCs). These mutations are …

Non small cell lung cancer (NSCLC) is the leading cause of cancer deaths in the United
States and worldwide. Unfortunately, standard therapies remain inadequate. An increased …

During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …