The strategies to cure cancer patients by eradicating cancer stem-like cells

Y Mai, J Su, C Yang, C Xia, L Fu - Molecular Cancer, 2023 - Springer
Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable
capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a …

On the potential origin and characteristics of cancer stem cells

JE Trosko - Carcinogenesis, 2021 - academic.oup.com
The 'cancer stem cell'hypothesis has pointed to a specific target for new cancer therapies.
The hypothesis is based on the observation that only the 'cancer stem cell'among the other …

20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells

O Shuvalov, Y Kirdeeva, E Fefilova, S Netsvetay… - Metabolites, 2023 - mdpi.com
20-Hydroxyecdysone (20E) is an arthropod hormone which is synthesized by some plants
as part of their defense mechanism. In humans, 20E has no hormonal activity but possesses …

NNK from tobacco smoking enhances pancreatic cancer cell stemness and chemoresistance by creating a β2AR‐Akt feedback loop that activates autophagy

X Chen, W Zhang, R Liu, Z Zhu, M Gong… - Molecular …, 2022 - Wiley Online Library
Low responsiveness to chemotherapy is an important cause of poor prognosis in pancreatic
cancer. Smoking is a high‐risk factor for pancreatic cancer and cancer resistance to …

Mouse uterine stem cells are affected by endocrine disruption and initiate uteropathies

P Singh, D Bhartiya - Reproduction, 2023 - rep.bioscientifica.com
In brief Incidence of uteropathies has increased in recent times, possibly due to exposure to
endocrine-disrupting chemicals during early development. The present study shows that …

A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness

X Huang, S Zhang, J Tang, T Tian, Y Pan, L Wu… - Cancer Research, 2023 - AACR
Elevated IgG expression in cancer cells has been implicated in exacerbated malignancy
and poor clinical prognosis. Accumulating evidence indicates that a nonconventional …

The talented LncRNAs: meshing into transcriptional regulatory networks in cancer

D Segal, J Dostie - Cancers, 2023 - mdpi.com
Simple Summary Long non-coding RNAs (lncRNAs) are a large class of RNA molecules
known to regulate the expression of genes. Although expressed in a highly tissue-specific …

High OCT4 expression might be associated with an aggressive phenotype in rectal cancer

L Lambis-Anaya, M Fernández-Ruiz, Y Liscano… - Cancers, 2023 - mdpi.com
Simple Summary The oncofetal protein OCT4 is a factor that promotes self-renewal and
maintenance of pluripotency of embryonic stem cells and induced stem cells, which has …

[HTML][HTML] Markers and reporters to reveal the hierarchy in heterogeneous cancer stem cells

A Mohan, R Raj Rajan, G Mohan… - Frontiers in cell and …, 2021 - frontiersin.org
A subpopulation within cancer, known as cancer stem cells (CSCs), regulates tumor
initiation, chemoresistance, and metastasis. At a closer look, CSCs show functional …

Dysregulated stem cell markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in inflammatory breast Cancer

TS Haiduk, M Sicking, KA Brücksken… - Archives of Medical …, 2023 - Elsevier
Background and aim While preliminary evidence points to pro-tumorigenic roles for the
Musashi (MSI) RNA-binding proteins Musashi-1 (MSI1) and Musashi-2 (MSI2) in some …