Aging hallmarks and progression and age-related diseases: a landscape view of research advancement
Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …
Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view
Autophagy is a highly conserved, lysosome-dependent biological mechanism involved in
the degradation and recycling of cellular components. There is growing evidence that …
the degradation and recycling of cellular components. There is growing evidence that …
Ganoderic acid D prevents oxidative stress‐induced senescence by targeting 14‐3‐3ε to activate CaM/CaMKII/NRF2 signaling pathway in mesenchymal stem cells
H Yuan, Y Xu, Y Luo, JR Zhang, XX Zhu, JH Xiao - Aging Cell, 2022 - Wiley Online Library
Stem cell senescence is an important cause of aging. Delaying senescence may present a
novel way to combat aging and age‐associated diseases. This study provided a mechanistic …
novel way to combat aging and age‐associated diseases. This study provided a mechanistic …
[HTML][HTML] COVID-19 patients with high TNF/IFN-γ levels show hallmarks of PANoptosis, an inflammatory cell death
Y Palacios, LA Ramón-Luing, A Ruiz… - Microbes and …, 2023 - Elsevier
TNF and IFN-γ trigger cell damage during SARS CoV-2 infection; these cytokines can
induce senescence and a cell death process called PANoptosis. This study included 138 …
induce senescence and a cell death process called PANoptosis. This study included 138 …
D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder
Aging is a risk factor for disease via increased susceptibility to infection, decreased ability to
maintain homeostasis, inefficiency in combating stress, and decreased regenerative …
maintain homeostasis, inefficiency in combating stress, and decreased regenerative …
Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components
R Sharma, B Diwan, A Sharma, JM Witkowski - Biogerontology, 2022 - Springer
Immunological aging is strongly associated with the observable deleterious effects of human
aging. Our understanding of the causes, effects, and therapeutics of aging immune cells has …
aging. Our understanding of the causes, effects, and therapeutics of aging immune cells has …
Contribution of viral and bacterial infections to senescence and immunosenescence
A Reyes, G Ortiz, LF Duarte, C Fernández… - Frontiers in cellular …, 2023 - frontiersin.org
Cellular senescence is a key biological process characterized by irreversible cell cycle
arrest. The accumulation of senescent cells creates a pro-inflammatory environment that can …
arrest. The accumulation of senescent cells creates a pro-inflammatory environment that can …
Recent advances in strategies for imaging detection and intervention of cellular senescence
J Li, Z Bi, L Wang, Y Xia, Y Xie, Y Liu - ChemBioChem, 2023 - Wiley Online Library
Cellular senescence is a stable cell cycle arrest state that can be triggered by a wide range
of intrinsic or extrinsic stresses. Increased burden of senescent cells in various tissues is …
of intrinsic or extrinsic stresses. Increased burden of senescent cells in various tissues is …
CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?
E Manousakis, CM Miralles, MG Esquerda… - International Journal of …, 2023 - mdpi.com
Cyclin-dependent kinase inhibitor 1A (Cip1/Waf1/CDKN1A/p21) is a well-established
protein, primarily recognised for its pivotal role in the cell cycle, where it induces cell cycle …
protein, primarily recognised for its pivotal role in the cell cycle, where it induces cell cycle …