Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly

E Derhovanessian, AB Maier, K Hähnel… - The Journal of …, 2014 - journals.aai.org
Influenza remains a major pathogen in older people. Infection with CMV and the
accumulation of late-differentiated T cells associated with it have been implicated in poor Ab …

How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?

AE Aiello, YL Chiu, D Frasca - Geroscience, 2017 - Springer
Cytomegalovirus (CMV) is an important pathogen for both clinical and population settings.
There is a growing body of research implicating CMV in multiple health outcomes across the …

Comprehensive circular RNA profiling reveals that circular RNA100783 is involved in chronic CD28-associated CD8 (+) T cell ageing

Y Wang, X Yu, S Luo, H Han - Immunity & Ageing, 2015 - Springer
Background Ageing brings about the gradual deterioration of the immune system, also
known as immunosenescence. The role of non-coding circular RNA in immunosenescence …

Quantification of T-cell dynamics during latent cytomegalovirus infection in humans

SPH van den Berg, LY Derksen, J Drylewicz… - PLoS …, 2021 - journals.plos.org
Cytomegalovirus (CMV) infection has a major impact on the T-cell pool, which is thought to
be associated with ageing of the immune system. The effect on the T-cell pool has been …

Aging and immunity–impact of behavioral intervention

L Müller, G Pawelec - Brain, behavior, and immunity, 2014 - Elsevier
Immune responses to pathogens to which they were not previously exposed are commonly
less effective in elderly people than in young adults, whereas those to agents previously …

Проточная цитометрия в биомедицинских исследованиях

АВ Зурочка, СВ Хайдуков, ИВ Кудрявцев… - 2018 - elibrary.ru
В монографии изложены современные взгляды на применение проточной
цитофлуориметрии в норме и при различных патологических процессах. Приведена …

Desirability and feasibility of a vaccine against cytomegalovirus

P Griffiths, S Plotkin, E Mocarski, R Pass, M Schleiss… - Vaccine, 2013 - Elsevier
Publication of a report from the Institute of Medicine in 2000 showing that a vaccine against
cytomegalovirus (CMV) would likely be cost saving was very influential and encouraged the …

Cytomegalovirus and Epstein–Barr virus co-infected young and middle-aged adults can have an aging-related T-cell phenotype

MI Hofstee, A Cevirgel, ML de Zeeuw-Brouwer… - Scientific Reports, 2023 - nature.com
Cytomegalovirus (CMV) is known to alter circulating effector memory or re-expressing
CD45RA+ (TemRA) T-cell numbers, but whether Epstein–Barr virus (EBV) does the same or …

Antiviral therapy can reverse the development of immune senescence in elderly mice with latent cytomegalovirus infection

M Beswick, A Pachnio, SN Lauder, C Sweet… - Journal of …, 2013 - Am Soc Microbiol
Cytomegalovirus (CMV) infection leads to the development of adaptive and humoral
immune responses that are among the largest for any pathogen, and intriguingly, the …

Inflammatory co-morbidities in HIV+ individuals: learning lessons from healthy ageing

AC Hearps, GE Martin, R Rajasuriar… - Current HIV/AIDS …, 2014 - Springer
Increased life expectancy due to improved efficacy of cART has uncovered an increased risk
of age-related morbidities in HIV+ individuals and catalyzed significant research into …