Alterations in the circulating CD8+ T cell pool, with a loss of naïve and accumulation of
effector/effector memory cells, are pronounced in older adults. However, homeostatic forces …

Aging is associated with an increased susceptibility to infections and diseases. It has also
been associated with reduced functionality and altered distribution of immune cells …

Introduction Previous research indicates that premature T cell senescence is a characteristic
of major depressive disorder (MDD). However, known senescence inducing factors like …

Human T cells expressing CD 56 are capable of tumour cell lysis following activation with
interleukin‐2 but their role in viral immunity has been less well studied. Proportions of CD …

Alzheimer's disease (AD) has been associated with increased local inflammation in the
affected brain regions, and in some studies also with elevated levels of proinflammatory …

Background Immunosenescence (ISC) describes age-related changes in immune-system
composition and function. Multiple sclerosis (MS) is a lifelong inflammatory condition …

Like all somatic tissues, the human immune system changes with age. This is believed to
result in an increased frequency of, and susceptibility to, infectious disease and to contribute …

Abstract Background. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) induce effector
memory T-cell expansions, which are variable and potentially depend on the age at primary …

Socioeconomic and demographic factors including educational attainment, race and
ethnicity, and childhood socioeconomic status (SES) are powerful predictors of inequalities …

Background Numbers of blood leukocyte subsets are highly dynamic in childhood and differ
greatly between subjects. Interindividual variation is only partly accounted for by genetic …