Lifespan socioeconomic context is associated with cytomegalovirus and late-differentiated CD8+ T and NK cells: initial results in older adults
RG Reed, AR Hillmann, SR Presnell… - Psychosomatic …, 2024 - journals.lww.com
Objective Lower socioeconomic status (SES) can accelerate immune aging; however, it is
unknown whether and how lifespan socioeconomic context (SEC)—the relative wealth and …
unknown whether and how lifespan socioeconomic context (SEC)—the relative wealth and …
Perceived stress, cytomegalovirus titers, and late-differentiated T and NK cells: Between-, within-person associations in a longitudinal study of older adults
RG Reed, SR Presnell, A Al-Attar, CT Lutz… - Brain, Behavior, and …, 2019 - Elsevier
Cytomegalovirus (CMV) and psychological stress are implicated as drivers of immunological
aging. It is unknown, however, whether associations among CMV titers, stress, and immune …
aging. It is unknown, however, whether associations among CMV titers, stress, and immune …
The impact of inflationary cytomegalovirus‐specific memory T cells on anti‐tumour immune responses in patients with cancer
XH Luo, Q Meng, M Rao, Z Liu, G Paraschoudi… - …, 2018 - Wiley Online Library
Human cytomegalovirus (CMV) is a ubiquitous, persistent beta herpesvirus. CMV infection
contributes to the accumulation of functional antigen‐specific CD 8+ T‐cell pools with an …
contributes to the accumulation of functional antigen‐specific CD 8+ T‐cell pools with an …
CD4: 8 ratio> 5 is associated with a dominant naive T-cell phenotype and impaired physical functioning in CMV-seropositive very elderly people: results from the …
W Adriaensen, E Derhovanessian… - … Series A: Biomedical …, 2015 - academic.oup.com
A subset of older people is at increased risk of hospitalization and dependency. Emerging
evidence suggests that immunosenescence reflected by an inverted CD4: 8 ratio and …
evidence suggests that immunosenescence reflected by an inverted CD4: 8 ratio and …
[HTML][HTML] Cytotoxic CD4+ tissue-resident memory T cells are associated with asthma severity
S Herrera-De La Mata, C Ramírez-Suástegui, H Mistry… - Med, 2023 - cell.com
Background Patients with severe uncontrolled asthma represent a distinct endotype with
persistent airway inflammation and remodeling that is refractory to corticosteroid treatment …
persistent airway inflammation and remodeling that is refractory to corticosteroid treatment …
Immune parameters associated with mortality in the elderly are context-dependent: lessons from Sweden, Holland and Belgium
G Pawelec - Biogerontology, 2018 - Springer
Abstract The pioneering Swedish OCTO/NONA-Immune longitudinal studies led by Anders
Wikby in Jönköping in the 1990s established a cluster of simple baseline immune …
Wikby in Jönköping in the 1990s established a cluster of simple baseline immune …
[HTML][HTML] PD-1 analysis on CD28− CD27− CD4 T cells allows stimulation-independent assessment of CMV viremic episodes in transplant recipients
J Dirks, H Tas, T Schmidt, S Kirsch, BC Gärtner… - American Journal of …, 2013 - Elsevier
Expression of the inhibitory receptor programmed death 1 (PD-1) on cytomegalovirus (CMV)-
specific CD4 T cells defines a phenotype associated with CMV viremia in transplant …
specific CD4 T cells defines a phenotype associated with CMV viremia in transplant …
Association between human herpes virus seropositivity and frailty in the elderly: A systematic review and meta-analysis
ACA Carvalho, MLT Mendes, VS Santos… - Ageing research …, 2018 - Elsevier
Frailty is an emerging geriatric syndrome characterized by decreased physiologic reserve
and increased vulnerability to environmental factors. Several studies have examined the …
and increased vulnerability to environmental factors. Several studies have examined the …
[HTML][HTML] Understanding the mechanism of action of cytomegalovirus-induced regulatory T cells
A Tovar-Salazar, A Weinberg - Virology, 2020 - Elsevier
We previously showed that CMV-induced CD4+ CD27− CD28− T cells have regulatory
(Treg) function. Here we sought to identify the target/s and the mechanistic underpinning/s of …
(Treg) function. Here we sought to identify the target/s and the mechanistic underpinning/s of …
[HTML][HTML] Latent CMV infection is associated with lower influenza virus-specific memory T-cell frequencies, but not with an impaired T-cell response to acute influenza …
SPH Van den Berg, J Lanfermeijer… - Frontiers in …, 2021 - frontiersin.org
Latent infection with cytomegalovirus (CMV) is assumed to contribute to the age-associated
decline of the immune system. CMV induces large changes in the T-cell pool and may …
decline of the immune system. CMV induces large changes in the T-cell pool and may …