Immune responses demonstrate a high level of intra-species variation, compensating for the
specialization capacity of pathogens. The recent advent of in-depth immune phenotyping …

Abstract Serum, cerebrospinal fluid (CSF), and cryopreserved lymphocytes from subjects in
the Rush Alzheimer's Disease Center Religious Orders Study were analyzed for …

The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined.
We generated deep epigenomes comprising genome-wide profiles of DNA methylation …

Upon cytomegalovirus (CMV) infection, large T-cell responses are elicited that remain high
or even increase over time, a phenomenon named memory T-cell inflation. Besides, the …

On antigen encounter, naïve CD8+ and CD4+ T cells differentiate into a large number of
effector cells that migrate to inflamed tissues to fight infections or tumors. Following …

Dysregulated immunity,'immunosenescence', in the elderly is thought to contribute to their
increased susceptibility to infectious disease and to impact on mortality. Accepted hallmarks …

Aging is associated with a progressive decline of innate and adaptive immune responses,
called immunosenescence. This phenomenon links to different multiple sclerosis (MS) …

Cytomegalovirus is the most frequent cause of intrauterine infection and the commonest
infectious agent to affect allograft recipients, yet the virus is acknowledged rarely as an …

ACLF is a specific, but complex and multifactorial form of acute decompensation of cirrhosis
and is characterized by an extraordinary dynamic natural course, rapidly evolving organ …

Introduction Many people with long COVID symptoms suffer from debilitating neurologic post-
acute sequelae of SARS-CoV-2 infection (Neuro-PASC). Although symptoms of Neuro …