Age-related changes in CD8 T cell homeostasis and immunity to infection

J Nikolich-Žugich, G Li, JL Uhrlaub, KR Renkema… - Seminars in …, 2012 - Elsevier
Studies of CD8 T cell responses to vaccination or infection with various pathogens in both
animal models and human subjects have revealed a markedly consistent array of age …

Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination

E Derhovanessian, H Theeten, K Hähnel… - Vaccine, 2013 - Elsevier
Influenza vaccination is less effective in the elderly compared to the young. Studies that
have attempted to identify immune parameters correlating with satisfactory vaccine …

Pathogenic features of CD4+ CD28–T cells in immune disorders

B Broux, S Markovic-Plese, P Stinissen… - Trends in molecular …, 2012 - cell.com
Aging of the immune system contributes to the increased morbidity and mortality of the
elderly population and may occur prematurely in patients with immune disorders. One of the …

[图书][B] Exercise immunology

M Gleeson, N Bishop, N Walsh - 2013 - api.taylorfrancis.com
Exercise immunology is an important, emerging sub-discipline within exercise physiology,
concerned with the relationship between exercise, immune function and infection risk. This …

[HTML][HTML] Pretransplant interferon-γ secretion by CMV-specific CD8+ T cells informs the risk of CMV replication after transplantation

S Cantisán, R Lara, M Montejo, J Redel… - American Journal of …, 2013 - Elsevier
In this prospective study we analyzed pretransplant interferon-γ secretion by
cytomegalovirus (CMV)-specific CD8+ T cells to assess its possible utility in determining the …

Impact of aging and cytomegalovirus on immunological response to influenza vaccination and infection

S Merani, G Pawelec, GA Kuchel… - Frontiers in …, 2017 - frontiersin.org
The number of people over the age of 60 is expected to double by 2050 according to the
WHO. This emphasizes the need to ensure optimized resilience to health stressors in late …

[PDF][PDF] Human cytomegalovirus (HCMV) infection/re-infection: development of a protective HCMV vaccine

G Gerna, D Lilleri - New Microbiol, 2019 - newmicrobiologica.org
Prof. Giuseppe Gerna E-mail: g. gerna@ smatteo. pv. it© 2019 by EDIMES-Edizioni
Internazionali Srl. All rights reserved is primary infection of a seronegative pregnant mother …

T lymphocyte senescence is attenuated in Parkinson's disease

A Kouli, M Jensen, V Papastavrou, KM Scott… - Journal of …, 2021 - Springer
Background Immune involvement is well-described in Parkinson's disease (PD), including
an adaptive T lymphocyte response. Given the increasing prevalence of Parkinson's disease …

Analysis of T and NK cell subsets in the Sicilian population from young to supercentenarian: The role of age and gender

ME Ligotti, A Aiello, G Accardi, S Aprile… - Clinical & …, 2021 - academic.oup.com
Ageing dramatically affects number and function of both innate and adaptive arms of
immune system, particularly T cell subsets, contributing to reduced vaccination efficacy …

Associations of cytomegalovirus infection with all-cause and cardiovascular mortality in multiple observational cohort studies of older adults

S Chen, G Pawelec, S Trompet… - The Journal of …, 2021 - academic.oup.com
Background Whether latent cytomegalovirus (CMV) infection in older adults has any
substantial health consequences is unclear. Here, we sought associations between CMV …