Introduction Previous research indicates that premature T cell senescence is a characteristic
of major depressive disorder (MDD). However, known senescence inducing factors like …

Background Psychosocial stress is thought to play a key role in the acceleration of
immunological aging. This study investigated the relationship between lifetime and past …

With age, the immune system becomes less effective, causing increased susceptibility to
infection. Chronic CMV infection further impairs immune function and is associated with …

Immune memory—comprising T cells, B cells and plasma cells and their secreted antibodies—
is crucial for human survival. It enables the rapid and effective clearance of a pathogen after …

Human herpesviruses including cytomegalovirus, Epstein–Barr virus, HHV6, HHV7, HHV8,
Herpes simplex virus (HSV)-1 and HSV-2 and varicella zoster virus (VZV) have developed …

Cytomegalovirus (CMV) has been described as a contributor to immunosenescence, thus
exacerbating age-related diseases. In persons with latent CMV infection, the CD8+ T cell …

Autoreactivity may play a critical role in the chronification of atopic dermatitis (AD). Several
studies showed that AD patients produce IgE Abs specific for autoantigens, and we …

BCG vaccine has been used for 100 years to prevent tuberculosis. Not all countries,
including the United States, adopted the initial World Health Organization recommendation …

According to the current paradigm, the main cause of AD is the accumulation of neurotoxic
amyloid beta (Aβ) peptide aggregates resulting from the cleavage of the amyloid precursor …

CD4+ T cells are essential for human CMV infection control. CMV-specific CD4+ T cells
possess antiviral functions and participate in anti-CMV humoral/cellular responses. In the …