SARS-CoV-2-specific immune response and the pathogenesis of COVID-19

E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …

Immune response in COVID-19: what is next?

Q Li, Y Wang, Q Sun, J Knopf, M Herrmann… - Cell Death & …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …

[PDF][PDF] Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19

Q Guo, Y Zhao, J Li, J Liu, X Yang, X Guo, M Kuang… - Cell host & …, 2021 - cell.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an
unprecedented public health crisis. Evidence suggests that SARS-CoV-2 infection causes …

A scoping review of the pathophysiology of COVID-19

PE Marik, J Iglesias, J Varon… - International journal of …, 2021 - journals.sagepub.com
COVID-19 is a highly heterogeneous and complex medical disorder; indeed, severe COVID-
19 is probably amongst the most complex of medical conditions known to medical science …

COVID-19: inflammatory profile

Y Wang, S Perlman - Annual review of medicine, 2022 - annualreviews.org
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of
coronavirus disease 2019 (COVID-19), has resulted in a pandemic that has had widespread …

The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review

AK Zaidi, P Dehgani-Mobaraki - The Journal of antibiotics, 2022 - nature.com
Considering the urgency of the ongoing COVID-19 pandemic, detection of new mutant
strains and potential re-emergence of novel coronaviruses, repurposing of drugs such as …

Syncytia formation during SARS-CoV-2 lung infection: a disastrous unity to eliminate lymphocytes

L Lin, Q Li, Y Wang, Y Shi - Cell Death & Differentiation, 2021 - nature.com
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, has become a major threat to the global public health …

Covid-19 interstitial pneumonia: histological and immunohistochemical features on cryobiopsies

C Doglioni, C Ravaglia, M Chilosi, G Rossi, A Dubini… - Respiration, 2021 - karger.com
Background: The pathogenetic steps leading to Covid-19 interstitial pneumonia remain to be
clarified. Most postmortem studies to date reveal diffuse alveolar damage as the most …

TNF‐α/IFN‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV‐2 receptor expression via hyper‐activated JAK/STAT1

R Kandhaya‐Pillai, X Yang, T Tchkonia, GM Martin… - Aging cell, 2022 - Wiley Online Library
Older age and underlying conditions such as diabetes/obesity or immunosuppression are
leading host risk factors for developing severe complications from COVID‐19 infection. The …

Covid‐19 and liver injury: role of inflammatory endotheliopathy, platelet dysfunction, and thrombosis

MJ McConnell, R Kondo, N Kawaguchi… - Hepatology …, 2022 - Wiley Online Library
Liver injury, characterized predominantly by elevated aspartate aminotransferase and
alanine aminotransferase, is a common feature of coronavirus disease 2019 (COVID‐19) …