Delirium pathophysiology: an updated hypothesis of the etiology of acute brain failure

JR Maldonado - International journal of geriatric psychiatry, 2018 - Wiley Online Library
Background Delirium is the most common neuropsychiatric syndrome encountered by
clinicians dealing with older adults and the medically ill and is best characterized by 5 core …

Predisposing and precipitating factors associated with delirium: a systematic review

CH Ormseth, SC LaHue, MA Oldham… - JAMA network …, 2023 - jamanetwork.com
Importance Despite discrete etiologies leading to delirium, it is treated as a common end
point in hospital and in clinical trials, and delirium research may be hampered by the attempt …

Delirium in elderly people

SK Inouye, RGJ Westendorp, JS Saczynski - The lancet, 2014 - thelancet.com
Delirium is an acute disorder of attention and cognition in elderly people (ie, those aged 65
years or older) that is common, serious, costly, under-recognised, and often fatal. A formal …

Neuropathogenesis of delirium: review of current etiologic theories and common pathways

JR Maldonado - The American Journal of Geriatric Psychiatry, 2013 - Elsevier
Delirium is a neurobehavioral syndrome caused by dysregulation of neuronal activity
secondary to systemic disturbances. Over time, a number of theories have been proposed in …

Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial

VJ Page, EW Ely, S Gates, XB Zhao, T Alce… - The lancet Respiratory …, 2013 - thelancet.com
Background Delirium is frequently diagnosed in critically ill patients and is associated with
poor clinical outcomes. Haloperidol is the most commonly used drug for delirium despite …

The neuroinflammatory hypothesis of delirium

J Cerejeira, H Firmino, A Vaz-Serra… - Acta …, 2010 - Springer
Delirium is a neuropsychiatric syndrome characterized by a sudden and global impairment
in consciousness, attention and cognition. It is particularly frequent in elderly subjects with …

Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients

Y Shehabi, RR Riker, PM Bokesch… - Critical care …, 2010 - journals.lww.com
Objectives: To determine the relationship between the number of delirium days experienced
by intensive care patients and mortality, ventilation time, and intensive care unit stay …

Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery

JR Maldonado, A Wysong, PJA Van Der Starre, T Block… - Psychosomatics, 2009 - Elsevier
Background Delirium is a neurobehavioral syndrome caused by the transient disruption of
normal neuronal activity secondary to systemic disturbances. Objective The authors …

[HTML][HTML] Anticholinergic drug burden and delirium: a systematic review

A Egberts, R Moreno-Gonzalez, H Alan, G Ziere… - Journal of the American …, 2021 - Elsevier
Objectives To investigate the association between anticholinergic drug burden (ADB),
measured with anticholinergic drug scales, and delirium and delirium severity. Design …

Association of delirium response and safety of pharmacological interventions for the management and prevention of delirium: a network meta-analysis

YC Wu, PT Tseng, YK Tu, CY Hsu, CS Liang… - JAMA …, 2019 - jamanetwork.com
Importance Although several pharmacological interventions for delirium have been
investigated, their overall benefit and safety remain unclear. Objective To evaluate evidence …