Sjögren's syndrome (SS) is a chronic autoimmune disease with the pathological hallmark of
lymphoplasmacytic infiltration of exocrine glands-more specifically salivary and lacrimal …

Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients
with radiation therapy for head and neck cancer and patients with Sjögren's syndrome …

Sjögren's syndrome is a chronic autoimmune disorder whose pathogenesis is poorly
understood and that lacks effective therapies. Detailed quantitative and spatial analyses of …

Salivary gland damage caused by ionizing radiation (IR) severely affects the patient quality
of life and influences the efficacy of radiotherapy. Most current treatment modalities are …

Aquaporins (AQPs) are a family of transmembrane water channels expressed in all living
organisms. AQPs facilitate osmotically driven water flux across biological membranes and …

Aquaporin-5 (AQP5), belonging to the aquaporins (AQPs) family of transmembrane water
channels, facilitates osmotically driven water flux across biological membranes and the …

Longer-term deterioration in saliva secretion has been observed to occur in response to
aging. The functional deterioration of the salivary gland damages swallowing and chewing …

Xerostomia, the subjective feeling of a dry mouth associated with dysfunction of the salivary
glands, is mainly caused by radiation and chemotherapy, various systemic and autoimmune …

Polydipsia and xerostomia are the most common complications that seriously affect oral
health in patients with diabetes. However, to date, there is no effective treatment for diabetic …

Aquaporins (AQPs) are a family of membrane water channel proteins that control osmotically-
driven water transport across cell membranes. Recent studies have focused on the …