Neurological and psychiatric diseases have high degrees of genetic and pathophysiological
heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have …

Genome-wide association studies have identified hundreds of robust genetic associations
underlying psychiatric disorders and provided important biological insights into disease …

Females with autism spectrum disorder (ASD) have been long overlooked in neuroscience
research, but emerging evidence suggests they show distinct phenotypic trajectories and …

Neuropsychiatric genome-wide association studies (GWASs), including those for autism
spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the …

Background Psychiatric conditions show overlap in their symptoms, genetics, and
involvement in brain areas and circuits. Structural alterations in the brain have been found to …

In the second half of the twentieth century, twin and family studies established beyond a
reasonable doubt that all forms of psychopathology are substantially heritable and highly …

Most neuropsychiatric disorders are highly polygenic, implicating hundreds to thousands of
causal genetic variants that span much of the genome. This widespread polygenicity …

Methodological advances over the last three decades have led to a profound transformation
in our understanding of the genetic origins of neuropsychiatric disorders. This is exemplified …

We explore how functional genomics approaches that integrate datasets from human and
non-human model systems can improve our understanding of the effect of gene …

Noncoding RNAs (ncRNAs) represent the majority of the transcriptome and play important
roles in regulating neuronal functions. ncRNAs are exceptionally diverse in both structure …