Understanding COVID-19-associated coagulopathy

EM Conway, N Mackman, RQ Warren… - Nature Reviews …, 2022 - nature.com
Abstract COVID-19-associated coagulopathy (CAC) is a life-threatening complication of
SARS-CoV-2 infection. However, the underlying cellular and molecular mechanisms driving …

Therapeutic targeting of the complement system: from rare diseases to pandemics

P Garred, AJ Tenner, TE Mollnes - Pharmacological reviews, 2021 - ASPET
The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

A multisystem, cardio-renal investigation of post-COVID-19 illness

AJ Morrow, R Sykes, A McIntosh, A Kamdar, C Bagot… - Nature medicine, 2022 - nature.com
The pathophysiology and trajectory of post-Coronavirus Disease 2019 (COVID-19)
syndrome is uncertain. To clarify multisystem involvement, we undertook a prospective …

COVID-19 infection: viral macro-and micro-vascular coagulopathy and thromboembolism/prophylactic and therapeutic management

AS Manolis, TA Manolis, AA Manolis… - Journal of …, 2021 - journals.sagepub.com
Coronavirus-2019 (COVID-19) predisposes patients to arterial and venous thrombosis
commonly complicating the clinical course of hospitalized patients and attributed to the …

[HTML][HTML] Complement C4, infections, and autoimmune diseases

H Wang, M Liu - Frontiers in immunology, 2021 - frontiersin.org
Complement C4, a key molecule in the complement system that is one of chief constituents
of innate immunity for immediate recognition and elimination of invading microbes, plays an …

Endothelial cell–activating antibodies in COVID‐19

H Shi, Y Zuo, S Navaz, A Harbaugh… - Arthritis & …, 2022 - Wiley Online Library
Objective While endothelial dysfunction has been implicated in the widespread
thromboinflammatory complications of COVID‐19, the upstream mediators of …

Approaches towards fighting the COVID‑19 pandemic

SC Tsai, CC Lu, DT Bau, YJ Chiu… - International …, 2021 - spandidos-publications.com
Abstract The coronavirus disease 2019 (COVID‑19) outbreak, which has caused> 46
millions confirmed infections and> 1.2 million coronavirus related deaths, is one of the most …

Multiple-organ complement deposition on vascular endothelium in COVID-19 patients

P Macor, P Durigutto, A Mangogna, R Bussani… - Biomedicines, 2021 - mdpi.com
Increased levels of circulating complement activation products have been reported in COVID-
19 patients, but only limited information is available on complement involvement at the …

[HTML][HTML] Complement activation via the lectin and alternative pathway in patients with severe COVID-19

J Niederreiter, C Eck, T Ries, A Hartmann… - Frontiers in …, 2022 - frontiersin.org
Complement plays an important role in the direct defense to pathogens, but can also
activate immune cells and the release of pro-inflammatory cytokines. However, in critically ill …

COVID-19 vaccines induce severe hemolysis in paroxysmal nocturnal hemoglobinuria

GF Gerber, X Yuan, J Yu, BAY Cher… - Blood, The Journal …, 2021 - ashpublications.org
COVID-19 vaccines induce severe hemolysis in paroxysmal nocturnal hemoglobinuria | Blood |
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