The brain is the most lipid-rich organ in the body and, owing to the impermeable nature of
the blood–brain barrier, lipid and lipoprotein metabolism within this organ is distinct from the …

Despite intense interest, the molecular mechanisms underlying the association of apoE4
with Alzheimer disease are not clear. Because the function (or dysfunction) of a protein is …

Lipoprotein metabolism in brain has not yet been fully elucidated, although there are a few
reports concerning lipids in the brain and lipoproteins and apolipoproteins in the …

Oxidation has been proposed to be an important factor in the pathogenesis of Alzheimer's
disease (AD) and amyloid β is considered to induce oxidation. In biological fluids, including …

The diagnosis of Alzheimer's disease (AD) is currently based on clinical and
neuropsychological examination. To date there is no blood test available that can …

Objective The purpose of this study was to examine the levels of cerebrospinal fluid (CSF)
apolipoprotein E (apoE) species in Alzheimer's disease (AD) patients. Methods We …

We investigated the lipoprotein distribution and composition in cerebrospinal fluid (CSF) in a
group of patients with Alzheimer's disease (AD) or affected by other types of dementia in …

We propose the hypothesis that small high‐density lipoprotein (HDL) particles reduce the
risk of Alzheimer's disease (AD) by virtue of their capacity to exchange lipids, affecting …

The ε4 allele of apolipoprotein E (ApoE) is a risk factor for Alzheimer's disease (AD). ApoE,
which is important for lipid metabolism, is also a major constituent of cerebrospinal fluid …

Cerebrovascular dysfunction significantly contributes to the clinical presentation and
pathoetiology of Alzheimer's disease (AD). Deposition and aggregation of β-amyloid (Aβ) …