Proteostasis is defined as the integrated mechanisms within cells that control protein
biogenesis, folding, trafficking and degradation. 1 The integrity of the proteome is essential …

Recent studies of cerebrospinal fluid (CSF) have shown increased oxidation of CSF
lipoproteins in Alzheimer's disease (AD) patients, and neurotoxicity from oxidized CSF …

Background SorLA/LR11 is a transmembrane neuronal sorting protein that reduces amyloid
precursor protein (APP) trafficking to secretases, notably BACE1 that generates beta …

AD is the most common dementia, afflicting millions in developed countries [1]. AD is a
neurodegenerative process characterized by irreversible destruction of the neocortex …

Abstract Patients with Alzheimer's Disease (AD) exhibit substantial cerebrovascular
damage, including the accumulation of β-amyloid (Aβ) peptides within the vessel wall. Mid …

Amyloid-beta (Aβ) plaques are a major neuropathological feature of Alzheimer's disease
(AD). These plaques are primarily composed of aggregates of Aβ peptides generated via the …

ApoE is a polymorphic protein that has been found to play many different roles in biological
processes including lipid transport, neurobiology and immunoregulation. ApoE occurs in the …

Sowohl im Stoffwechsel der Lipoproteine im Plasma als auch im cerebralen
Lipoproteinmetabolimus spielt das Apolipoprotein E eine zentrale Rolle. Im Zusammenhang …

Alzheimer's disease (AD) is a progressive neurodegenerative disorders with no known cure.
AD presents a huge social and economic burden to our society. Numerous studies point out …

Previously, our lab has found that CSF lipoproteins from AD patients contain reduced
concentrations of polyunsaturated fatty acids, a signature of increased lipid peroxidation …