Phase separations in oncogenesis, tumor progressions and metastasis: a glance from hallmarks of cancer

LW Zheng, CC Liu, KD Yu - Journal of Hematology & Oncology, 2023 - Springer
Liquid–liquid phase separation (LLPS) is a novel principle for interpreting precise
spatiotemporal coordination in living cells through biomolecular condensate (BMC) …

Rational drug design targeting intrinsically disordered proteins

H Wang, R Xiong, L Lai - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
Intrinsically disordered proteins (IDPs) are proteins that perform important biological
functions without well‐defined structures under physiological conditions. IDPs can form …

DisProt in 2024: improving function annotation of intrinsically disordered proteins

MC Aspromonte, MV Nugnes, F Quaglia… - Nucleic Acids …, 2024 - academic.oup.com
Abstract DisProt (URL: https://disprot. org) is the gold standard database for intrinsically
disordered proteins and regions, providing valuable information about their functions. The …

PED in 2024: improving the community deposition of structural ensembles for intrinsically disordered proteins

H Ghafouri, T Lazar, A Del Conte… - Nucleic acids …, 2024 - academic.oup.com
Abstract The Protein Ensemble Database (PED)(URL: https://proteinensemble. org) is the
primary resource for depositing structural ensembles of intrinsically disordered proteins. This …

The HIV capsid mimics karyopherin engagement of FG-nucleoporins

CF Dickson, S Hertel, AJ Tuckwell, N Li, J Ruan… - Nature, 2024 - nature.com
HIV can infect non-dividing cells because the viral capsid can overcome the selective barrier
of the nuclear pore complex and deliver the genome directly into the nucleus,. Remarkably …

CAID prediction portal: a comprehensive service for predicting intrinsic disorder and binding regions in proteins

A Del Conte, A Bouhraoua, M Mehdiabadi… - Nucleic Acids …, 2023 - academic.oup.com
Intrinsic disorder (ID) in proteins is well-established in structural biology, with increasing
evidence for its involvement in essential biological processes. As measuring dynamic ID …

An intrinsically disordered region controlling condensation of a circadian clock component and rhythmic transcription in the liver

K Zhu, IJ Celwyn, D Guan, Y Xiao, X Wang, W Hu… - Molecular cell, 2023 - cell.com
Circadian gene transcription is fundamental to metabolic physiology. Here we report that the
nuclear receptor REV-ERBα, a repressive component of the molecular clock, forms circadian …

DEPICTER2: a comprehensive webserver for intrinsic disorder and disorder function prediction

S Basu, J Gsponer, L Kurgan - Nucleic Acids Research, 2023 - academic.oup.com
Intrinsic disorder in proteins is relatively abundant in nature and essential for a broad
spectrum of cellular functions. While disorder can be accurately predicted from protein …

Natural proteome diversity links aneuploidy tolerance to protein turnover

J Muenzner, P Trébulle, F Agostini, H Zauber… - Nature, 2024 - nature.com
Accessing the natural genetic diversity of species unveils hidden genetic traits, clarifies gene
functions and allows the generalizability of laboratory findings to be assessed. One notable …

Comparative evaluation of AlphaFold2 and disorder predictors for prediction of intrinsic disorder, disorder content and fully disordered proteins

B Zhao, S Ghadermarzi, L Kurgan - Computational and Structural …, 2023 - Elsevier
We expand studies of AlphaFold2 (AF2) in the context of intrinsic disorder prediction by
comparing it against a broad selection of 20 accurate, popular and recently released …